UniProt Accession

 CD3G_HUMAN; P09693; Q2HIZ6 

Genbank Protein ID

 X04145; X06026; X06027; X06028; X06029; X06030; X06031; BC113830 

Genbank Nucleotide ID

 CAA27764.1; CAA29428.1; CAA29428.1; CAA29428.1; CAA29428.1; CAA29428.1; CAA29428.1; AAI13831.1 

Protein Name

 T-cell surface glycoprotein CD3 gamma chain 

Protein Synonyms/Alias

 T-cell receptor T3 gamma chain; CD3g 

Gene Name

 CD3G 

Gene Synonyms/Alias

 T3G 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	IKGNHLVKVYDYQED	ubiquitination	[1]
57	AKNITWFKDGKMIGF	ubiquitination	[1]
60	ITWFKDGKMIGFLTE	ubiquitination	[1]
69	IGFLTEDKKKWNLGS	ubiquitination	[1]
70	GFLTEDKKKWNLGSN	ubiquitination	[1]
71	FLTEDKKKWNLGSNA	ubiquitination	[1]
79	WNLGSNAKDPRGMYQ	ubiquitination	[1, 2]
88	PRGMYQCKGSQNKSK	ubiquitination	[1]
95	KGSQNKSKPLQVYYR	ubiquitination	[1]
150	RQSRASDKQTLLPND	ubiquitination	[1, 2, 3]
164	DQLYQPLKDREDDQY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 The CD3 complex mediates signal transduction. 

Sequence Annotation

 DOMAIN 37 94 Ig-like.
 DOMAIN 149 177 ITAM.
 MOTIF 153 154 Di-leucine motif.
 MOD_RES 145 145 Phosphoserine.
 MOD_RES 148 148 Phosphoserine.
 CARBOHYD 52 52 N-linked (GlcNAc...) (Potential).
 CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
 DISULFID 46 87  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0042105; C:alpha-beta T cell receptor complex; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0042101; C:T cell receptor complex; NAS:UniProtKB.
 GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.
 GO:0042608; F:T cell receptor binding; NAS:UniProtKB.
 GO:0004888; F:transmembrane signaling receptor activity; IMP:UniProtKB.
 GO:0007163; P:establishment or maintenance of cell polarity; IMP:UniProtKB.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0006461; P:protein complex assembly; NAS:UniProtKB.
 GO:0015031; P:protein transport; IMP:UniProtKB.
 GO:0070228; P:regulation of lymphocyte apoptotic process; IMP:UniProtKB.
 GO:0042110; P:T cell activation; NAS:UniProtKB.
 GO:0031295; P:T cell costimulation; TAS:Reactome.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR015484; CD3_gsu/dsu.
 IPR013783; Ig-like_fold.
 IPR003598; Ig_sub2.
 IPR003110; Phos_immunorcpt_sig_ITAM. 

Pfam

 PF02189; ITAM 

SMART

 SM00408; IGc2
 SM00077; ITAM 

PROSITE

 PS50835; IG_LIKE
 PS51055; ITAM_1 

PRINTS