CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Casein kinase 2, beta polypeptide, isoform CRA_d 
Protein Synonyms/Alias
 Casein kinase II subunit beta 
Gene Name
 CSNK2B 
Gene Synonyms/Alias
 hCG_43725 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119GIAQMLEKYQQGDFGubiquitination[1, 2]
153IPGEAMVKLYCPKCMubiquitination[2]
158MVKLYCPKCMDVYTPubiquitination[2, 3]
166CMDVYTPKSSRHHHTubiquitination[1, 2]
210VPRLYGFKIHPMAYQubiquitination[2, 4]
227LQAASNFKSPVKTIRubiquitination[2, 3, 4]
231SNFKSPVKTIR****ubiquitination[2, 3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 234 AA 
Protein Sequence
MEKCKGTSRM AGTTSADVKM SSSEEVSWIS WFCGLRGNEF FCEVDEDYIQ DKFNLTGLNE 60
QVPHYRQALD MILDLEPDEE LEDNPNQSDL IEQAAEMLYG LIHARYILTN RGIAQMLEKY 120
QQGDFGYCPR VYCENQPMLP IGLSDIPGEA MVKLYCPKCM DVYTPKSSRH HHTDGAYFGT 180
GFPHMLFMVH PEYRPKRPAN QFVPRLYGFK IHPMAYQLQL QAASNFKSPV KTIR 234 
Gene Ontology
 GO:0005956; C:protein kinase CK2 complex; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0019887; F:protein kinase regulator activity; IEA:InterPro.
 GO:0045859; P:regulation of protein kinase activity; IEA:GOC. 
Interpro
 IPR016149; Casein_kin_II_reg-sub_a-hlx.
 IPR016150; Casein_kin_II_reg-sub_b-sht.
 IPR000704; Casein_kinase_II_reg-sub. 
Pfam
 PF01214; CK_II_beta 
SMART
 SM01085; CK_II_beta 
PROSITE
 PS01101; CK2_BETA 
PRINTS
 PR00472; CASNKINASEII.