CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007508
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signaling mucin HKR1 
Protein Synonyms/Alias
 Hansenula MRAKII killer toxin-resistant protein 1 
Gene Name
 HKR1 
Gene Synonyms/Alias
 YDR420W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
1525HPRNCIGKSLNNEREubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta- glucan synthesis. Overexpression provides resistance to HM-1 killer toxin. 
Sequence Annotation
 REPEAT 453 480 1; approximate.
 REPEAT 481 508 2.
 REPEAT 509 536 3.
 REPEAT 537 564 4.
 REPEAT 565 592 5.
 REPEAT 593 620 6.
 REPEAT 621 648 7.
 REPEAT 649 676 8.
 REPEAT 677 704 9.
 REPEAT 705 732 10.
 REPEAT 733 760 11.
 REPEAT 761 788 12.
 REGION 453 788 12 X 28 AA tandem repeats of S-[AV]-[P]-
 CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1252 1252 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1293 1293 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1342 1342 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1400 1400 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1802 AA 
Protein Sequence
MVSLKIKKIL LLVSLLNAIE AYSNDTIYST SYNNGIESTP SYSTSAISST GSSNKENAIT 60
SSSETTTMAG QYGESGSTTI MDEQETGTSS QYISVTTTTQ TSDTMSSVKK STEIATPSSS 120
IVPTPLQSYS DESQISQTLS HNPKSVAESD SDTTSSESSS SVIISTSDSS AVPREISPII 180
TTDSQISKEE GTLAQTSSIS ETTRIAQMVT RVSQISSITA ASTIDGFSSE STQTDFSNTV 240
SFENSVEEEY AMSKSQLSES YSSSSTVYSG GESTADKTSS SPITSFSSSY SQTTSTETSE 300
SSRVAVGVSR PSSITQTTSI DSFSMSEVEL STYYDLSAGN YPDQELIVDR PATSSTAETS 360
SEASQGVSRE SNTFAVSSIS TTNFIVSSAS DTVVSTSSTN TVPYSSVHST FVHATSSSTY 420
ISSSLYSSPS LSASVSSHFG VAPFPSAYIS FSSVPVAVSS TYTSSPSASV VVPSAYASSP 480
SVPVAVSSTY TSSPSAPAAI SSTYTSSPSA PVAVSSTYTS SPSAPAAISS TYTSSPSAPV 540
AVSSTYTSSP SAPAAISSTY TSSPSAPVAV SSTYTSSPSA PVAISSTYTS SPSVPVAVSS 600
TYTSSPSAPA AISSTYTSSP SAPVAVSSTY TSSPSAPAAI SSTYTSSPSV PVAVSSTYTS 660
SPSAPAAISS TYTSSPSVPV AVSSTYTSSP SAPAAISSTY TSSPSAPVAV SSTYTSSPSA 720
PAAISSTYTS SPSAPVAVSS TYTSSPSAPA AISSTYTSSP SAPVAVSSTY TSSPSALVVL 780
SSTSTSSPYD IVYSPSTFAA ISSGYTPSPS ASVAMSSTSS SSPYDIVYSL SSSASRSSIA 840
TYEFSPSPST SLPTSSTYTY FSSAYAFEFS SERYSTTSTI APTQIHSTLS RITDFLLQTS 900
MAIQSIVSQQ ISTSSTLNDE IHSSALSVFN PSASNLVETS LIISSTQASI TSPKNSAKIS 960
SLQSQLSSST KNPYDTANKN TETSGRSTVV SNFLYTSSAA KPDNEKFSAT PTEITTISSS 1020
SHAYSLSIPS SHNSVTGLSH NFVDSSKSAT SFGYSSSSIS SIKLSKETIP ASKSVSNTQE 1080
RITSFTSTLR ANSQSEKSEG RNSVGSLQSS HISSNPSLST NTKVDSKSLS RKVSKTMGEN 1140
GEETGLTTTK TQYKSSSETS GSYSRSFTKI SIGPATTAVQ TQASTNSVFT APALSTYPTT 1200
PYPSPNSYAW LPTAIIVESS ETGPTTASFN PSITGSLPNA IEPAVAVSEP INHTLITIGF 1260
TAALNYVFLV QNPLSSAQIF NFLPLVLKYP FSNTSSELDN SIGELSTFIL SYRSGSSTTT 1320
LSPKSISSLS VVKKKKNQQK KNATKSTEDL HPPQVDTSSI AVKKIVPMVD SSKAYIVSVA 1380
EVYFPTEAVT YLQQLILDEN STLYSNPQTP LRSLAGLIDS GIPLGGLTLY GSGDGGYVPS 1440
LTSSSVLDSS KGNSQNIDGT YKYGALDDFI NSFTDSASAG KYAVKIIIFL IVLTIGVLLW 1500
LFVAFFAFRH RNILLKRHPR NCIGKSLNNE RELESTELSR SSSGNQVYNE KPPESENESV 1560
YSAVDDHYIV TGENTVYNTI HRLHYTINDD GDLLYRDAIP LDFDQTNGDD GSGIDSIVRD 1620
CVYDKNQDAT EAFLNDEESI SGILDVDENG DIRLYDSYSD NEESNSFHLP DEVIENYNKN 1680
HLCETKLHGL GTESCTTDDP DTGNQITNEF STGSQTCLPS TAYTTPLHTN SIKLHTLRYT 1740
ESSLPKPNQT LFSNLEDLEI EDIDDNGSVS DVHIEELDAL DEELYKRMSK VIKQQNHQTT 1800
KI 1802 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0030427; C:site of polarized growth; IDA:SGD.
 GO:0005034; F:osmosensor activity; IGI:SGD.
 GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IMP:SGD.
 GO:0000282; P:cellular bud site selection; IMP:SGD.
 GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
 GO:0006972; P:hyperosmotic response; IGI:SGD.
 GO:0007232; P:osmosensory signaling pathway via Sho1 osmosensor; IGI:SGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS