UniProt Accession

 MCU_HUMAN; Q8NE86; B2RDF3; B3KXV7; Q96FL3 

Genbank Protein ID

 AK315519; AK128016; AC016542; AC069548; CH471083; BC010682; BC034235 

Genbank Nucleotide ID

 BAG37900.1; BAG54619.1; EAW54461.1; AAH10682.1; AAH34235.1 

Protein Name

 Calcium uniporter protein, mitochondrial 

Protein Synonyms/Alias

 Coiled-coil domain-containing protein 109A 

Gene Name

 MCU 

Gene Synonyms/Alias

 C10orf42; CCDC109A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
211	IERLEDLKEQLAPLE	ubiquitination	[1, 2]
219	EQLAPLEKVRIEISR	ubiquitination	[2]
332	AQAEMDLKRLRDPLQ	acetylation	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. 

Sequence Annotation

  

Keyword

 Alternative splicing; Calcium; Calcium channel; Calcium transport; Coiled coil; Complete proteome; Ion channel; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 351 AA 

Protein Sequence

Gene Ontology

 GO:0034704; C:calcium channel complex; ISS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
 GO:0005262; F:calcium channel activity; IDA:UniProtKB.
 GO:0015292; F:uniporter activity; IDA:UniProtKB.
 GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IDA:UniProtKB.
 GO:0042593; P:glucose homeostasis; IMP:UniProtKB.
 GO:0006851; P:mitochondrial calcium ion transport; IDA:UniProtKB.
 GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.
 GO:0035786; P:protein complex oligomerization; IDA:UniProtKB. 

Interpro

 IPR006769; Coiled-coil-dom_prot_109_C. 

Pfam

 PF04678; DUF607 

SMART

  

PROSITE

  

PRINTS