UniProt Accession

 ICT1_HUMAN; Q14197; B2RAD1; Q53HM7; Q53Y11 

Genbank Protein ID

 X81788; BT007111; AK222553; AK314138; CH471099; BC015335 

Genbank Nucleotide ID

 CAA57387.1; AAP35775.1; BAD96273.1; BAG36828.1; EAW89227.1; AAH15335.1 

Protein Name

 Peptidyl-tRNA hydrolase ICT1, mitochondrial 

Protein Synonyms/Alias

 Digestion substraction 1; DS-1; Immature colon carcinoma transcript 1 protein 

Gene Name

 ICT1 

Gene Synonyms/Alias

 DS1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	KSIYSLDKLYPESQG	ubiquitination	[1]
66	WRVPNGAKQADSDIP	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. 

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Mitochondrion; Polymorphism; Protein biosynthesis; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB.
 GO:0004045; F:aminoacyl-tRNA hydrolase activity; IDA:UniProtKB.
 GO:0016150; F:translation release factor activity, codon nonspecific; IDA:UniProtKB.
 GO:0070126; P:mitochondrial translational termination; IDA:UniProtKB. 

Interpro

 IPR000352; Pep_chain_release_fac_I_II. 

Pfam

 PF00472; RF-1 

SMART

  

PROSITE

 PS00745; RF_PROK_I 

PRINTS