CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034475
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 S-adenosylmethionine decarboxylase proenzyme 
Protein Synonyms/Alias
  
Gene Name
 Amd2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96KALVPLLKLARDYSGubiquitination[1]
291LFVNQSSKCRTVLSSubiquitination[1]
301TVLSSPQKIDGFKRLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 68 68 Schiff-base intermediate with substrate;
 ACT_SITE 82 82 Proton donor; for catalytic activity (By
 ACT_SITE 229 229 Proton acceptor; for processing activity
 ACT_SITE 243 243 Proton acceptor; for processing activity
 MOD_RES 68 68 Pyruvic acid (Ser); by autocatalysis (By  
Keyword
 Complete proteome; Decarboxylase; Lyase; Polyamine biosynthesis; Pyruvate; Reference proteome; S-adenosyl-L-methionine; Schiff base; Spermidine biosynthesis; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 334 AA 
Protein Sequence
MEAAHFFEGT EKLLEVWFSR QQSDASQGSG DLRTIPRSEW DVLLKDVQCS IISVTKTDKQ 60
EAYVLSESSM FVSKRRFILK TCGTTLLLKA LVPLLKLARD YSGFDSIQSF FYSRKNFMKP 120
SHQGYPHRNF QEEIEFLNAI FPNGAAYCMG RMNSDCWYLY TLDFPESRVI SQPDQTLEIL 180
MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TLFNPCGYSM NGMKSDGTYW 240
TIHITPEPEF SYVSFETNLS QTSYDHLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLSSPQ 300
KIDGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS 334 
Gene Ontology
 GO:0004014; F:adenosylmethionine decarboxylase activity; IDA:MGI.
 GO:0006557; P:S-adenosylmethioninamine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008295; P:spermidine biosynthetic process; IEA:UniProtKB-KW.
 GO:0006597; P:spermine biosynthetic process; IEA:InterPro. 
Interpro
 IPR001985; S-AdoMet_decarboxylase.
 IPR018167; S-AdoMet_decarboxylase_subgr.
 IPR016067; S-AdoMet_deCO2ase_core.
 IPR018166; S-AdoMet_deCO2ase_CS. 
Pfam
 PF01536; SAM_decarbox 
SMART
  
PROSITE
 PS01336; ADOMETDC 
PRINTS