CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027538
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase, cAMP dependent regulatory, type II alpha 
Protein Synonyms/Alias
 Protein kinase, cAMP dependent regulatory, type II alpha, isoform CRA_b; cAMP-dependent protein kinase type II-alpha regulatory chain; cAMP-dependent protein kinase type II-alpha regulatory subunit 
Gene Name
 Prkar2a 
Gene Synonyms/Alias
 mCG_16488 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
159AMFEKIVKTDEHVIDubiquitination[1]
248KNNAKKRKMFESFIEubiquitination[1]
278IVDVIGEKIYKDGERubiquitination[1]
343ELALVTNKPRAASAYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 402 AA 
Protein Sequence
MSHIQIPAGL TELLQGYTVE VLRQQPPDLV DFAVEYFTRL REARRQESDT FIVSPTTFHT 60
QESSAVPVIE EDGESDSDSE DADLEVPVPS KFTRRVSVCA ETFNPDEEEE DNDPRVVHPK 120
TDEQRCRLQE ACKDILLFKN LDQEQLSQVL DAMFEKIVKT DEHVIDQGDD GDNFYVIERG 180
TYDILVTKDN QTRSVGQYDN RGSFGELALM YNTPRAATII ATSEGSLWGL DRVTFRRIIV 240
KNNAKKRKMF ESFIESVPLF KSLEMSERMK IVDVIGEKIY KDGERIIAQG EKADSFYIIE 300
SGEVSILIRS KTKSNKNGGN QEVEIAHCHK GQYFGELALV TNKPRAASAY AVGDVKCLVM 360
DVQAFERLLG PCMDIMKRNI SHYEEQLVKM FGSNLDLMDP GQ 402 
Gene Ontology
 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF02197; RIIa 
SMART
 SM00100; cNMP
 SM00394; RIIa 
PROSITE
 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 
PRINTS
 PR00103; CAMPKINASE.