CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017087
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Angiomotin-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 AMOTL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145LPTYEEAKAQSQFFRubiquitination[1]
177MAGGTSQKSRTEGRPubiquitination[1]
239SGNGKGFKVGGGPSPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. 
Sequence Annotation
 MOTIF 953 956 PDZ-binding.
 MOD_RES 241 241 Phosphoserine.
 MOD_RES 295 295 Phosphoserine.
 MOD_RES 720 720 Phosphoserine.
 MOD_RES 793 793 Phosphoserine (By similarity).
 MOD_RES 805 805 Phosphoserine (By similarity).
 MOD_RES 906 906 Phosphoserine.  
Keyword
 Alternative splicing; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Tight junction; Ubl conjugation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 956 AA 
Protein Sequence
MWRAKLRRGT CEPAVKVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG 60
TPTENMNLLA IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT 120
VMEKQVRSTQ PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT 180
EGRPTVNRAN SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV 240
GGGPSPAQPA GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP 300
APQPVRTDVA VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP 360
LPMALGAPQP PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH 420
KFEKELQRIS EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS 480
SREYEGHEDK AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA 540
RVIKLEEELR EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH 600
GNGQPANMPE YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA 660
ERDTTIINHS RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK 720
VLQQRSRKDA GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG 780
LLLGKEHHEH ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM 840
ASLPSRGRLS TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE 900
MMEVLI 906 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0003365; P:establishment of cell polarity involved in ameboidal cell migration; IEA:Compara.
 GO:0035329; P:hippo signaling cascade; TAS:Reactome.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR009114; Angiomotin.
 IPR024646; Angiomotin_C. 
Pfam
 PF12240; Angiomotin_C 
SMART
  
PROSITE
  
PRINTS
 PR01807; ANGIOMOTIN.