CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arf-GAP with dual PH domain-containing protein 2 
Protein Synonyms/Alias
 Centaurin-alpha-2; Cnt-a2 
Gene Name
 Adap2 
Gene Synonyms/Alias
 Centa2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127QEFTAIDKAVSHPGNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity). 
Sequence Annotation
 DOMAIN 9 132 Arf-GAP.
 DOMAIN 132 233 PH 1.
 DOMAIN 255 361 PH 2.
 ZN_FING 25 48 C4-type.  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; GTPase activation; Membrane; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 381 AA 
Protein Sequence
MGDRERNKKR LLELLQAAGT GNGHCADCGA ADPDWASYKL GIFICLHCSG VHRNFPDISK 60
VKSVRLDFWD DSMVEFMTHH GNLNVKAKFE ARVPAFYYVP QANDCLVLKE QWIRAKYERQ 120
EFTAIDKAVS HPGNREGFLW KRGRDNAQFL RRRFVLLSRE GLLKYYTKEE GKAPKAVISI 180
KDLNATFQTE KIGHPHGLQI TYRKEGHTRN LFVYHDSGKE IVDWFNALRA ARLQYLKLAF 240
PDLPESELVP LITRNYLKQG FMEKTGPKHR EPFKKRWFAL DPQERRLLYY KNPLDAFELG 300
QVFLGSNEQG YEVWEDLPKG IRGNRWKAGL TVITPERKFI FTCPTEKEQR EWLESLRGVL 360
SSPLSPLHLL TTSAETGCGL G 381 
Gene Ontology
 GO:0005740; C:mitochondrial envelope; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; ISS:UniProtKB.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; ISS:UniProtKB.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007507; P:heart development; NAS:UniProtKB.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. 
Interpro
 IPR001164; ArfGAP.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01412; ArfGap
 PF00169; PH 
SMART
 SM00105; ArfGap
 SM00233; PH 
PROSITE
 PS50115; ARFGAP
 PS50003; PH_DOMAIN 
PRINTS
 PR00405; REVINTRACTNG.