[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
Functional Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity).
Sequence Annotation
REGION 307 531 Interaction with POU5F1 (By similarity). REGION 389 433 Intersubunit contact. REGION 432 437 D-fructose 1,6-bisphosphate binding; part REGION 514 521 D-fructose 1,6-bisphosphate binding; part METAL 75 75 Potassium (By similarity). METAL 77 77 Potassium (By similarity). METAL 113 113 Potassium (By similarity). METAL 114 114 Potassium; via carbonyl oxygen (By METAL 272 272 Magnesium (By similarity). METAL 296 296 Magnesium (By similarity). BINDING 70 70 Serine (By similarity). BINDING 73 73 Substrate (By similarity). BINDING 106 106 Serine (By similarity). BINDING 295 295 Substrate; via amide nitrogen (By BINDING 296 296 Substrate; via amide nitrogen (By BINDING 328 328 Substrate (By similarity). BINDING 464 464 Serine (By similarity). BINDING 482 482 D-fructose 1,6-bisphosphate; part of BINDING 489 489 D-fructose 1,6-bisphosphate; part of MOD_RES 37 37 Phosphoserine (By similarity). MOD_RES 62 62 N6-acetyllysine (By similarity). MOD_RES 89 89 N6-acetyllysine (By similarity). MOD_RES 105 105 Phosphotyrosine (By similarity). MOD_RES 148 148 Phosphotyrosine (By similarity). MOD_RES 166 166 N6-acetyllysine (By similarity). MOD_RES 175 175 Phosphotyrosine (By similarity). MOD_RES 195 195 Phosphothreonine (By similarity). MOD_RES 266 266 N6-acetyllysine (By similarity). MOD_RES 305 305 N6-acetyllysine (By similarity). MOD_RES 408 408 4-hydroxyproline (By similarity).
Keyword
Acetylation; Allosteric enzyme; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Glycolysis; Hydroxylation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Potassium; Pyruvate; Reference proteome; Transferase; Ubl conjugation.