CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007025
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone-lysine N-methyltransferase, H3 lysine-4 specific 
Protein Synonyms/Alias
 COMPASS component SET1; Lysine N-methyltransferase 2; SET domain-containing protein 1 
Gene Name
 SET1 
Gene Synonyms/Alias
 KMT2; YTX1; YHR119W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
982PVAEMREKRYLKNGIacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. 
Sequence Annotation
 DOMAIN 938 1055 SET.
 DOMAIN 1064 1080 Post-SET.
 MOD_RES 625 625 Phosphoserine.
 MOD_RES 875 875 Phosphothreonine.  
Keyword
 3D-structure; Chromatin regulator; Chromosome; Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1080 AA 
Protein Sequence
MSNYYRRAHA SSGSYRQPQE QPQYSRSGHY QYSNGHSHQQ YSSQYNQRRR YNHNDGTRRR 60
YNDDRPHSSN NASTRQYYAT NNSQSGPYVN KKSDISSRRG MSQSRYSNSN VHNTLASSSG 120
SLPTESALLL QQRPPSVLRY NTDNLKSKFH YFDPIKGEFF NKDKMLSWKA TDKEFSETGY 180
YVVKELQDGQ FKFKIKHRHP EIKASDPRNE NGIMTSGKVA THRKCRNSLI LLPRISYDRY 240
SLGPPPSCEI VVYPAQDSTT TNIQDISIKN YFKKYGEISH FEAFNDPNSA LPLHVYLIKY 300
ASSDGKINDA AKAAFSAVRK HESSGCFIMG FKFEVILNKH SILNNIISKF VEINVKKLQK 360
LQENLKKAKE KEAENEKAKE LQGKDITLPK EPKVDTLSHS SGSEKRIPYD LLGVVNNRPV 420
LHVSKIFVAK HRFCVEDFKY KLRGYRCAKF IDHPTGIYII FNDIAHAQTC SNAESGNLTI 480
MSRSRRIPIL IKFHLILPRF QNRTRFNKSS SSSNSTNVPI KYESKEEFIE ATAKQILKDL 540
EKTLHVDIKK RLIGPTVFDA LDHANFPELL AKRELKEKEK RQQIASKIAE DELKRKEEAK 600
RDFDLFGLYG GYAKSNKRNL KRHNSLALDH TSLKRKKLSN GIKPMAHLLN EETDSKETTP 660
LNDEGITRVS KEHDEEDENM TSSSSEEEEE EAPDKKFKSE SEPTTPESDH LHGIKPLVPD 720
QNGSSDVLDA SSMYKPTATE IPEPVYPPEE YDLKYSQTLS SMDLQNAIKD EEDMLILKQL 780
LSTYTPTVTP ETSAALEYKI WQSRRKVLEE EKASDWQIEL NGTLFDSELQ PGSSFKAEGF 840
RKIADKLKIN YLPHRRRVHQ PLNTVNIHNE RNEYTPELCQ REESSNKEPS DSVPQEVSSS 900
RDNRASNRRF QQDIEAQKAA IGTESELLSL NQLNKRKKPV MFARSAIHNW GLYALDSIAA 960
KEMIIEYVGE RIRQPVAEMR EKRYLKNGIG SSYLFRVDEN TVIDATKKGG IARFINHCCD 1020
PNCTAKIIKV GGRRRIVIYA LRDIAASEEL TYDYKFEREK DDEERLPCLC GAPNCKGFLN 1080 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0048188; C:Set1C/COMPASS complex; IPI:SGD.
 GO:0042054; F:histone methyltransferase activity; ISS:SGD.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
 GO:0016279; F:protein-lysine N-methyltransferase activity; IMP:SGD.
 GO:0003723; F:RNA binding; IMP:SGD.
 GO:0030437; P:ascospore formation; IMP:SGD.
 GO:0000183; P:chromatin silencing at rDNA; TAS:SGD.
 GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
 GO:0051568; P:histone H3-K4 methylation; IDA:SGD.
 GO:0018027; P:peptidyl-lysine dimethylation; IMP:SGD.
 GO:0035066; P:positive regulation of histone acetylation; IGI:SGD.
 GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IMP:SGD.
 GO:0000723; P:telomere maintenance; IMP:SGD. 
Interpro
 IPR024657; COMPASS_Set1_N-SET.
 IPR017111; Hist_H3-K4_MeTrfase_1_fun.
 IPR015722; Histone-lysine_MeTfrase.
 IPR003616; Post-SET_dom.
 IPR024636; SET_assoc.
 IPR001214; SET_dom. 
Pfam
 PF11764; N-SET
 PF00856; SET
 PF11767; SET_assoc 
SMART
 SM00508; PostSET
 SM00317; SET 
PROSITE
 PS50868; POST_SET
 PS51572; SAM_MT43_1
 PS50280; SET 
PRINTS