| Tag | Content |
|---|
| CPLM ID | CPLM-014780 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Double-stranded RNA-binding protein Staufen homolog 2 |
Protein Synonyms/Alias | r-staufen protein |
Gene Name | Stau2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 81 | TLPKPVQKPPKSNVN | ubiquitination | [1] | | 106 | ELNGLAMKRGEPAIY | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body. |
Sequence Annotation | DOMAIN 8 75 DRBM 1.
DOMAIN 95 181 DRBM 2.
DOMAIN 207 274 DRBM 3.
DOMAIN 307 375 DRBM 4.
REGION 381 571 Required for dendritic transport.
MOTIF 273 317 Nuclear localization signal 1.
MOTIF 373 412 Nuclear localization signal 2.
MOD_RES 188 188 Phosphoserine (By similarity).
MOD_RES 395 395 Phosphoserine (By similarity).
MOD_RES 416 416 Phosphoserine (By similarity).
MOD_RES 426 426 Phosphoserine (By similarity).
MOD_RES 440 440 Phosphoserine (By similarity).
MOD_RES 456 456 Phosphoserine (By similarity).
MOD_RES 493 493 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Microtubule; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 571 AA |
Protein Sequence | MANPKEKTPM CLVNELARFH SIQPQYKLLN ESGPAHSKMF SVQLSLGEQT WESEGSSIKK 60
AQQAVANKAL TESTLPKPVQ KPPKSNVNNN PGSITPTVEL NGLAMKRGEP AIYRPLDPKP 120
FPNYRANYNF RGMYNQRYHC PMPKIFYVQL TVGNNEFFGE GKTRQAARHN AAMKALQALQ 180
NEPIPEKSPQ NGESGKEMDD DKDANKSEIS LVFEIALKRN MPVSFEVIKE SGPPHMKSFV 240
TRVSVGEFSA EGEGNSKKLS KKRAATTVLQ ELKKLPPLPV IEKPKLFFKK RPKTIIKAGP 300
EYGQGMNPIS RLAQIQQARK EKEPDYVLLS ERGMPRRREF VMQVKVGNEV ATGTGPNKKI 360
AKKNAAEAML LQLGYKASTS LQDQLDKTGE NKGWSGPKPG FPEPANNTPK GILHLSPDVY 420
QEMEASRHRV TSGTTLGYLS PKDMNQPSSS FFSVESPSPT SSAPAARELL MNGTSPAAEA 480
IGLKGSSPTP PCSSVQPSKQ LEYLARIQGF QAALSALKQF SEQGLESIDG VVNVENGSLE 540
KQAKHLREKA DNNQANPGSI TQDCKKSKSV I 571 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0003725; F:double-stranded RNA binding; IEA:InterPro. GO:0006810; P:transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |