| Tag | Content |
|---|
| CPLM ID | CPLM-017071 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nitric oxide-inducible gene protein |
Protein Synonyms/Alias | |
Gene Name | NOXIN |
Gene Synonyms/Alias | C11orf82 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 492 | IVKANCSKDDFLFNC | ubiquitination | [1] | | 619 | KQYCRWSKNQDDSFT | ubiquitination | [1] | | 733 | DFIQPSQKLSLQSLS | ubiquitination | [1] | | 794 | GINRAFKKPVFYSDL | ubiquitination | [1] | | 807 | DLDGNYEKIRIFPEN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as an anti-apoptotic factor and its absence increases cell death under normal and stress conditions. Can induce cell cycle arrest in the G1 or early S phase and this activity is independent of p53/TP53 (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Growth arrest; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 998 AA |
Protein Sequence | MNRRRKFLLA SVLALQNSSF IYPSCQKCFS RIILVSKRSN CPKCGSTGES GNANYRYKLS 60
LKVAESNKLF VITVFGSCLD TFFGLTATGL HRYIQDPNKI PETLDNDTTQ NLLTKAVETC 120
FVGQSFIFGV TNFENQPGQG SDASNFLQQC SDHKRKAKAL VACQIVLPDP GIAGFTVIDY 180
FHQLLQTFNF RKLQCDSQAP NNHLLALDHS NSDLSSIYTS DSTSDFFKSC SKDTFSKFWQ 240
PSLEFTCIVS QLTDNDDFSA SEQSKAFGTL QQNRKSISIA EATGSSSCHD PIQDSWSLVS 300
YMDKKSTAEK LGKELGLQAK ELSAVHSSHH EIGVNDSNLF SLEMREPLES SNTKSFHSAV 360
EIKNRSQHEL PCFQHHGIDT PTSLQKRSAC CPPSLLRLEE TASSSQDGDP QIWDDLPFSE 420
SLNKFLAVLE SEIAVTQADV SSRKHHVDND IDKFHADHSR LSVTPQRTTG ALHTPPIALR 480
SSQVIVKANC SKDDFLFNCK GNLSPSVEKE SQPDNKVEAV SVNHNGRDMS EYFLPNPYLS 540
ALSSSSKDLE TIVTLKKTIR ISPHRESDHS SLNNKYLNGC GEISVSEMNE KLTTLCYRKY 600
NDVSDLCKLE NKQYCRWSKN QDDSFTICRK LTYPLETLCN SPNRSTNTLK EMPWGHINNN 660
VTQSYSIGYE GSYDASADLF DDIAKEMDIA TEITKKSQDI LLKWGTSLAE SHPSESDFSL 720
RSLSEDFIQP SQKLSLQSLS DSRHSRTCSP TPHFQSDSEY NFENSQDFVP CSQSTPISGF 780
HQTRIHGINR AFKKPVFYSD LDGNYEKIRI FPENDKQQAS PSCPKNIKTP SQKIRSPIVS 840
GVSQPDVFNH YPFAECHETD SDEWVPPTTQ KIFPSDMLGF QGIGLGKCLA AYHFPDQQEL 900
PRKKLKHIRQ GTNKGLIKKK LKNMLAAVVT KKKTHKYNCK SSGWISKCPD IQVLAAPQLH 960
PILGPDSCSE VKCCLPFSEK GPPSVCETRS AWSPELFS 998 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0033554; P:cellular response to stress; IEA:Compara. GO:0030097; P:hemopoiesis; IEA:Compara. GO:0071850; P:mitotic cell cycle arrest; IEA:Compara. GO:2000270; P:negative regulation of fibroblast apoptotic process; IEA:Compara. GO:0007286; P:spermatid development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |