CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA, FLJ96840, highly similar to Homo sapiens valyl-tRNA synthetase 2-like (VARS2L), mRNA 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20HRFVAREKIMSVLSEubiquitination[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Ligase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 642 AA 
Protein Sequence
MTSLCGDWLQ GLHRFVAREK IMSVLSERGL FRGLQNHPMV LPICSRSGDV IEYLLKNQWF 60
VRCQEMGARA AKAVESGALE LSPSFHQKNW QHWFSHIGDW CVSRQLWWGH QIPAYLVVED 120
HAQGEEDCWV VGRSEAEARE VAAELTGRPG AELTLERDPD VLDTWFSSAL FPFSALGWPQ 180
ETPDLARFYP LSLLETGSDL LLFWVGRMVM LGTQLTGQLP FSKVLLHPMV RDRQGRKMSK 240
SLGNVLDPRD IISGVEMQLL QEKLRSGNLD PAELAIVAAA QKKDFPHGIP ECGTDALRFT 300
LCSHGVQAGD LHLSVSEVQS CRHFCNKIWN ALRFILNALG EKFVPQPAEE LSPSSPMDAW 360
ILSRLALAAQ ECERGFLTRE LSLVTHALHH FWLHNLCDVY LEAVKPVLWH SPRPLGPPQV 420
LFSCADLGLR LLAPLMPFLA EELWQRLPPR PGCPPAPSIS VAPYPSACSL EHWRQPELER 480
RFSRVQEVVQ VLRALRATYQ LTKARPRVLL QSSEPGGQGL FEAFLEPLGT LGYCGAVGLL 540
PPGTAAPSGW AQAPLSDTAQ VYMELQGLVD PQIQLPLLAA RRYKLQKQLD SLTARTPSEG 600
EAGTQRQQKL SSLQLELSKL DKAASHLRQL MDEPPAPGSP EL 642 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004832; F:valine-tRNA ligase activity; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC.
 GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002300; aa-tRNA-synth_Ia.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd.
 IPR013155; V/L/I-tRNA-synth_anticodon-bd.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit.
 IPR002303; Valyl-tRNA_ligase. 
Pfam
 PF08264; Anticodon_1
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
  
PRINTS
 PR00986; TRNASYNTHVAL.