CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004492
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sulfate/thiosulfate import ATP-binding protein CysA 
Protein Synonyms/Alias
 Sulfate-transporting ATPase 
Gene Name
 cysA 
Gene Synonyms/Alias
 b2422; JW2415 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
119AIKAKVTKLLEMVQLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. 
Sequence Annotation
 DOMAIN 3 237 ABC transporter.
 NP_BIND 35 42 ATP (Potential).  
Keyword
 ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Reference proteome; Sulfate transport; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 365 AA 
Protein Sequence
MSIEIANIKK SFGRTQVLND ISLDIPSGQM VALLGPSGSG KTTLLRIIAG LEHQTSGHIR 60
FHGTDVSRLH ARDRKVGFVF QHYALFRHMT VFDNIAFGLT VLPRRERPNA AAIKAKVTKL 120
LEMVQLAHLA DRYPAQLSGG QKQRVALARA LAVEPQILLL DEPFGALDAQ VRKELRRWLR 180
QLHEELKFTS VFVTHDQEEA TEVADRVVVM SQGNIEQADA PDQVWREPAT RFVLEFMGEV 240
NRLQGTIRGG QFHVGAHRWP LGYTPAYQGP VDLFLRPWEV DISRRTSLDS PLPVQVLEAS 300
PKGHYTQLVV QPLGWYNEPL TVVMHGDDAP QRGERLFVGL QHARLYNGDE RIETRDEELA 360
LAQSA 365 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015419; F:sulfate transmembrane-transporting ATPase activity; IEA:EC.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0008272; P:sulfate transport; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026251; ABC_ATP-bd_CysA.
 IPR014769; ABC_CysA_ATP-bd_C.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR008995; Mo/tungstate-bd_C_term_dom.
 IPR027417; P-loop_NTPase.
 IPR005666; Sulph_transpt1.
 IPR024765; TOBE-like. 
Pfam
 PF00005; ABC_tran
 PF12857; TOBE_3 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2
 PS51237; CYSA 
PRINTS