CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011888
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor CSR2 
Protein Synonyms/Alias
 CHS5 SPA2 rescue protein 2 
Gene Name
 CSR2 
Gene Synonyms/Alias
 MRG19; YPR030W; YP9367.10 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
841VHKIPQDKNHNEVNDubiquitination[1, 2, 3]
Reference
 [1] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [2] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [3] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging. 
Sequence Annotation
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 127 127 Phosphoserine.
 MOD_RES 327 327 Phosphoserine.
 MOD_RES 987 987 Phosphoserine.
 CROSSLNK 841 841 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Cytoplasm; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1121 AA 
Protein Sequence
MQSTVPIAIA SNGNKRDVVQ NVSAGDEGDI LQRLARNREM ISTSLSPQKS SGFSGRRRSS 60
SVRDALSSFF GTGNSPTSSM DDYSNLMNRN YSTASTAMCR GNSFPSDVGT KAYNITGSYQ 120
PDRHRNSVPY TTIDQLHTRQ DTGLRRESDP VAAKQISSNN DIVRSFITHH ASNSTMFINR 180
VLSDYLADRG FIKQTPLYNK KSVLEISIAT SAESVFLPTT KSDETEYLSL IHGSLNQART 240
QPVGSTNTAE SDFLPSCPTM DTLNENNDLS LFPLHTQRTS PSNTARTGNA MDTSNSDRAS 300
PASNNNTTDA DSFVASGNNN PMNNNNSPAR NRHPNSHSRS LPNAWNSQMP SFSFALIFSL 360
NKSTTLSDIK VELTSNVRVV WFNGLPPTKN VNEECYNIGS LDWTLNADNF NLFIPQGAKS 420
PLDIVENHSN NRKLKVLQKL SMRKRRSFSN KAVLRENILN NLNASNSTNK LNAGVYVFTI 480
PIVLASRIPE SLYYPSARVS YSLRLATKLK DEHTQLVASR PRSSSISSPQ KLRSYSCSDS 540
YEYSQIDDTI EGETYNNDKN STGKIAFPSS WLKSAKGRLK RNNSNGRSDN NGASSSGLAM 600
QHDSEDTINL QYPLNLVRTP PEISVTTANK PLYINKVWEN CLSYEISFAQ KYVPLNGEIP 660
ITIKVAPLVK SLSVKRIRVS CREKISYRSK DYQYDFDQLD PLASDPCNPY HMRYLVRKKK 720
DRSLPLFEVA SKCTSGPSIR EEVVTNTVDD NLLAYTSSKE NNKDIPFSES FTVKTKLKFP 780
KYCEVDATKA ASLPPYGIDL FDPIKDPTQS ENTSNNGNVL GFLVGRPNRA SKTVHKIPQD 840
KNHNEVNDTN GNSNTSLQTS SNVPIQHYTR LNKPRRGLYL DSMHFKNIQC SHKLEIVLRV 900
SKTDSGSSKI IRHYEVIVDT PIYLISDLCN TSNIDLPTYD MATTESSKVL PPTFEEATSV 960
SASPRSSVSY YPDDISMQQL NLSRSTSLAN GYLSTLHPKT TAVSDSSNGA PIRDQQEQQA 1020
RPLRTEDYAL QMGNENNAYS NMDGLLSQDI FEQETAATLF KRDIVTMNFN NNIFTPRYSP 1080
RTFTNTDYNY NDNDNNDNDT EGPGPIIHPG PEPPRYDEIS S 1121 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0031505; P:fungal-type cell wall organization; IGI:SGD.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0070086; P:ubiquitin-dependent endocytosis; ISA:SGD. 
Interpro
 IPR011022; Arrestin_C-like. 
Pfam
 PF02752; Arrestin_C 
SMART
 SM01017; Arrestin_C 
PROSITE
  
PRINTS