CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020645
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial calcium uniporter regulator 1 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 90A, mitochondrial 
Gene Name
 Mcur1 
Gene Synonyms/Alias
 Ccdc90a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
204ALQQVLSKIANVKKDacetylation[1]
231RAENEKIKLELHQLKacetylation[2]
253TKVRTDTKLNFNLEKacetylation[2, 3]
260KLNFNLEKSRVKELYacetylation[2, 4]
260KLNFNLEKSRVKELYsuccinylation[4]
264NLEKSRVKELYSLNEacetylation[2]
272ELYSLNEKKMLELRTacetylation[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
 Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Calcium; Calcium transport; Coiled coil; Complete proteome; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 340 AA 
Protein Sequence
MDSGSVAAER PRRTPSRQRL PSSGCGVPAR PGVSTLPGGR SWLRPRGRAA RASPLLFLLL 60
VPSPRLAATA TATAPRRTLA ERSRPGLVLP AAALGAGRNA LGRLRLGARR VAALASSRRE 120
LSLSAKCHQL EHRKENLPLS VSRQLYFDTH ALVCLLEANG FTIQQAEIIV SALVKITETN 180
MNIIYKDMVS KMQQEIALQQ VLSKIANVKK DMVILEKSEF SALRAENEKI KLELHQLKQQ 240
VMDEVTKVRT DTKLNFNLEK SRVKELYSLN EKKMLELRTE IVSLHAQQDR ALTQTDRKIE 300
TEVAGLKTML EAHKLDTIKY LAGSVFTCLT VALGFYRLWI 340 
Gene Ontology
 GO:0031305; C:integral to mitochondrial inner membrane; ISS:UniProtKB.
 GO:0070509; P:calcium ion import; ISS:UniProtKB.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; ISS:UniProtKB.
 GO:0006851; P:mitochondrial calcium ion transport; ISS:UniProtKB. 
Interpro
 IPR024461; DUF1640. 
Pfam
 PF07798; DUF1640 
SMART
  
PROSITE
  
PRINTS