CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020790
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 25 
Protein Synonyms/Alias
  
Gene Name
 Fbxo25 
Gene Synonyms/Alias
 Fbx25 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
145SLSGVAQKNYFNILDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT). 
Sequence Annotation
 DOMAIN 225 273 F-box.
 REGION 1 83 Interaction with beta-actin (By  
Keyword
 Actin-binding; Complete proteome; Nucleus; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 357 AA 
Protein Sequence
MPFLGQDWRS PGWSWIKTED GWKRCDPCSH ELRSEDSQYT INHSIILNSG EEEIFNNECE 60
YAAKKRKKEH FGNDTAAHSF YREKWIYVHK ESTKERHGYC TLGEAFNRLD FSSAIQDIRR 120
FTYVVKLLQL IAKSQLTSLS GVAQKNYFNI LDKIVQKVLD DHQNPRLIKG LLQDLSSTLG 180
ILVRGVGKSV LVGNINIWIC RLETVLSWQQ QLQNLQVTKQ VNTGLTLSDL PLHMLNNILY 240
RFSDGWDIVT LGQVTPTLYM LSEDRRLWKR LCQYHFAEQQ FCRHLILSEK GHIEWKLMYF 300
TLQKYYPTKE QYGDTLHFCR HCSILFWKDS GHPCTAADPD SCFTPVSPEH FIDLFKF 357 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB. 
Interpro
 IPR001810; F-box_dom_cyclin-like. 
Pfam
  
SMART
  
PROSITE
 PS50181; FBOX 
PRINTS