CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024382
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 320 
Protein Synonyms/Alias
  
Gene Name
 ZNF320 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23EFSQEEWKCLDPAQRubiquitination[1]
159RRIHTGEKPYKCEECubiquitination[2]
168YKCEECEKVFSCKSHubiquitination[3]
187RIIHTGEKPYKCKVCubiquitination[1, 3]
192GEKPYKCKVCDKAFKubiquitination[3]
224YTCNECGKVFDQKATubiquitination[3]
271HRLHTGEKPYKCNECubiquitination[1, 3, 4]
274HTGEKPYKCNECGKTubiquitination[1, 3]
364YKCKVCDKAFRSDSRubiquitination[3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 80 KRAB.
 ZN_FING 161 183 C2H2-type 1.
 ZN_FING 189 211 C2H2-type 2.
 ZN_FING 217 239 C2H2-type 3.
 ZN_FING 245 267 C2H2-type 4.
 ZN_FING 273 295 C2H2-type 5.
 ZN_FING 301 323 C2H2-type 6.
 ZN_FING 329 351 C2H2-type 7.
 ZN_FING 357 379 C2H2-type 8.
 ZN_FING 385 407 C2H2-type 9.
 ZN_FING 413 435 C2H2-type 10.
 ZN_FING 441 463 C2H2-type 11.
 ZN_FING 469 491 C2H2-type 12; degenerate.  
Keyword
 Chromosomal rearrangement; Complete proteome; DNA-binding; Metal-binding; Nucleus; Proto-oncogene; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMNTLSS 60
TGQGNTEVIH TGTLQRQASY HIGAFCSQEI EKDIHDFVFQ WQEDETNDHE APMTEIKKLT 120
SSTDRYDQRH AGNKPIKGQL ESRFHLHLRR HRRIHTGEKP YKCEECEKVF SCKSHLEIHR 180
IIHTGEKPYK CKVCDKAFKH DSHLAKHTRI HRGDKHYTCN ECGKVFDQKA TLACHHRSHT 240
GEKPYKCNEC GKTFSQTSHL VYHHRLHTGE KPYKCNECGK TFARNSVLVI HKAVHTAEKP 300
YKCNECGKVF KQRATLAGHR RVHTGEKPYR CEECDKVFSR KSHLERHRRI HTGEKPYKCK 360
VCDKAFRSDS RLAEHQRVHT GERPYTCNEC GKVFSTKAYL ACHQKLHTGE KLYECEECDK 420
VYIRKSHLER HRRIHTGEKP HKCGDCGKAF NSPSHLIRHQ RIHTGQKSYK CHQCGKVFSL 480
RSLLAEHQKI PFGDNCFKCN EYSKPSSIN 509 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS