UniProt Accession

 GFRP_HUMAN; P30047; B2R4L6; Q2M1Q2; Q99749 

Genbank Protein ID

 U78190; AK311872; CH471125; BC112262; BC112264 

Genbank Nucleotide ID

 AAB37337.1; BAG34813.1; EAW92443.1; AAI12263.1; AAI12265.1 

Protein Name

 GTP cyclohydrolase 1 feedback regulatory protein 

Protein Synonyms/Alias

 GFRP; GTP cyclohydrolase I feedback regulatory protein; p35 

Gene Name

 GCHFR 

Gene Synonyms/Alias

 GFRP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	PPRIVLDKLERRGFR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030425; C:dendrite; IDA:UniProtKB.
 GO:0042470; C:melanosome; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; IEA:Compara.
 GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
 GO:0043105; P:negative regulation of GTP cyclohydrolase I activity; IEA:Compara.
 GO:0042133; P:neurotransmitter metabolic process; TAS:ProtInc.
 GO:0006809; P:nitric oxide biosynthetic process; TAS:ProtInc.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR009112; GTP_CycHdrlase_I_reg. 

Pfam

 PF06399; GFRP 

SMART

  

PROSITE

  

PRINTS