CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008562
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 High mobility group protein HMGI-C 
Protein Synonyms/Alias
 High mobility group AT-hook protein 2 
Gene Name
 HMGA2 
Gene Synonyms/Alias
 HMGIC 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26PAAPAPQKRGRGRPRubiquitination[1]
66SPSKAAQKKAEATGEsumoylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome.
 Cao X, Clavijo C, Li X, Lin HH, Chen Y, Shih HM, Ann DK.
 Mol Cancer Ther. 2008 Apr;7(4):923-34. [PMID: 18413806] 
Functional Description
 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes (By similarity). 
Sequence Annotation
 DNA_BIND 24 34 A.T hook 1.
 DNA_BIND 44 54 A.T hook 2.
 DNA_BIND 71 82 A.T hook 3.
 REGION 44 63 Interaction with E4F1.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 40 40 Phosphothreonine.
 MOD_RES 44 44 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Cell cycle; Cell division; Chromosomal rearrangement; Complete proteome; Direct protein sequencing; DNA condensation; DNA-binding; Growth regulation; Mitosis; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 109 AA 
Protein Sequence
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP 60
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED 109 
Gene Ontology
 GO:0000228; C:nuclear chromosome; ISS:UniProtKB.
 GO:0032993; C:protein-DNA complex; IDA:UniProtKB.
 GO:0035985; C:senescence-associated heterochromatin focus; IDA:UniProtKB.
 GO:0071141; C:SMAD protein complex; IDA:UniProtKB.
 GO:0051575; F:5'-deoxyribose-5-phosphate lyase activity; IDA:UniProtKB.
 GO:0003680; F:AT DNA binding; IDA:UniProtKB.
 GO:0070742; F:C2H2 zinc finger domain binding; IMP:UniProtKB.
 GO:0035497; F:cAMP response element binding; IDA:UniProtKB.
 GO:0001047; F:core promoter binding; IDA:UniProtKB.
 GO:0008301; F:DNA binding, bending; IDA:UniProtKB.
 GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB.
 GO:0004677; F:DNA-dependent protein kinase activity; IDA:UniProtKB.
 GO:0035501; F:MH1 domain binding; IDA:UniProtKB.
 GO:0035500; F:MH2 domain binding; IDA:UniProtKB.
 GO:0031492; F:nucleosomal DNA binding; IDA:UniProtKB.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0006284; P:base-excision repair; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0021846; P:cell proliferation in forebrain; IEA:Compara.
 GO:0002062; P:chondrocyte differentiation; IDA:UniProtKB.
 GO:0035988; P:chondrocyte proliferation; IDA:UniProtKB.
 GO:0031052; P:chromosome breakage; IDA:UniProtKB.
 GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
 GO:0042769; P:DNA damage response, detection of DNA damage; IDA:UniProtKB.
 GO:0035987; P:endodermal cell differentiation; IMP:UniProtKB.
 GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
 GO:0045444; P:fat cell differentiation; IMP:UniProtKB.
 GO:0060613; P:fat pad development; IEA:Compara.
 GO:0035978; P:histone H2A-S139 phosphorylation; IDA:UniProtKB.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0048333; P:mesodermal cell differentiation; IMP:UniProtKB.
 GO:0003131; P:mesodermal-endodermal cell signaling; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IDA:UniProtKB.
 GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IDA:UniProtKB.
 GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; IDA:UniProtKB.
 GO:0045869; P:negative regulation of retroviral genome replication; IDA:UniProtKB.
 GO:0090402; P:oncogene-induced senescence; IDA:UniProtKB.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0071158; P:positive regulation of cell cycle arrest; IDA:UniProtKB.
 GO:2000685; P:positive regulation of cellular response to X-ray; IDA:UniProtKB.
 GO:2000774; P:positive regulation of cellular senescence; IMP:UniProtKB.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:2001022; P:positive regulation of response to DNA damage stimulus; IDA:UniProtKB.
 GO:2000648; P:positive regulation of stem cell proliferation; IDA:UniProtKB.
 GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:2001038; P:regulation of cellular response to drug; IDA:UniProtKB.
 GO:0060123; P:regulation of growth hormone secretion; IEA:Compara.
 GO:2000036; P:regulation of stem cell maintenance; IMP:UniProtKB.
 GO:0009615; P:response to virus; IEP:UniProtKB.
 GO:0035986; P:senescence-associated heterochromatin focus assembly; IDA:UniProtKB.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR020478; AT_hook-like.
 IPR017956; AT_hook_DNA-bd_motif.
 IPR000116; HMGI/HMGY.
 IPR000637; HMGI/Y_DNA-bd_CS. 
Pfam
 PF02178; AT_hook 
SMART
 SM00384; AT_hook 
PROSITE
 PS00354; HMGI_Y 
PRINTS
 PR00929; ATHOOK.
 PR00930; HIGHMOBLTYIY.