| Tag | Content |
|---|
| CPLM ID | CPLM-015205 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine--tRNA ligase, cytoplasmic |
Protein Synonyms/Alias | Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase |
Gene Name | Sars |
Gene Synonyms/Alias | Sars1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 55 | FRADNLNKLKNLCSK | acetylation | [1] | | 123 | KCDGERVKLEAERFE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity). |
Sequence Annotation | NP_BIND 302 304 ATP (By similarity).
NP_BIND 391 394 ATP (By similarity).
REGION 271 273 Serine binding (By similarity).
BINDING 318 318 ATP; via amide nitrogen and carbonyl
BINDING 325 325 Serine (By similarity).
BINDING 429 429 Serine (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 241 241 Phosphoserine (By similarity).
MOD_RES 323 323 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 512 AA |
Protein Sequence | MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC 60
SKTIGEKMKK KEPVGEDESI PEDVLNFDDL TADTLAALKV SQIKKVRLLV DEAIQKCDGE 120
RVKLEAERFE NLREIGNLLH PSVPISNDED ADNKVERIWG DCTVRKKYSH VDLVVMVDGF 180
EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY TPIYTPFFMR KEVMQEVAQL 240
SQFDEELYKV IGKGSEKSDD SSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGFSTC 300
FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FDEMITTAEE FYQSLGIPYH 360
IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKV 420
EFVHMLNATM CATTRTICAI LENYQTEKGI VVPEKLREFM PPGLQELIPF VKPAPIDQEP 480
SKKQKKQHEG SKKKAKEVTL ENQLQNMEVT EA 512 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004828; F:serine-tRNA ligase activity; IEA:EC. GO:0097056; P:selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |