CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023007
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FK506-binding protein-like 
Protein Synonyms/Alias
 WAF-1/CIP1 stabilizing protein 39; WISp39 
Gene Name
 FKBPL 
Gene Synonyms/Alias
 DIR1; NG7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
107PDGSFVKKIVIRGHGubiquitination[1]
287EREPGHLKALYRRGVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. 
Sequence Annotation
 REPEAT 210 243 TPR 1.
 REPEAT 252 285 TPR 2.
 REPEAT 286 319 TPR 3.  
Keyword
 Complete proteome; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 349 AA 
Protein Sequence
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL 60
EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL 120
GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH 180
SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL 240
LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG 300
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG 349 
Gene Ontology
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0009314; P:response to radiation; NAS:UniProtKB. 
Interpro
 IPR023566; PPIase_FKBP.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS