CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008751
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Squalene synthase 
Protein Synonyms/Alias
 SQS; SS; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 
Gene Name
 Fdft1 
Gene Synonyms/Alias
 Erg9 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
30GRRNFIPKMDQDSLSubiquitination[1]
41DSLSSSLKTCYKYLNubiquitination[1]
138EFRNLAEKYQTVIDDubiquitination[1]
229EDQQEGRKFWPQEVWubiquitination[1]
318KGVVKIRKGQAVTLMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway. 
Sequence Annotation
  
Keyword
 Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Isoprene biosynthesis; Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Multifunctional enzyme; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 416 AA 
Protein Sequence
MEFVKCLGHP EEFYNLLRFR MGGRRNFIPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA 60
LDGDIRHAIC VFYLVLRALD TVEDDMSISV EKKIPLLCNF HTFLYDPEWR FTESKEKDRQ 120
VLEDFPTISL EFRNLAEKYQ TVIDDICHRM GCGMAEFVDK DVTSKQDWDK YCHYVAGLVG 180
IGLSRLFSAS EFEDPIVGED IECANSMGLF LQKTNIIRDY LEDQQEGRKF WPQEVWGRYI 240
KKLEDFAKPE NVDVAVQCLN ELITNTLQHI PDVLTYLSRL RNQSVFNFCA IPQVMAIATL 300
AACYNNQQVF KGVVKIRKGQ AVTLMMDATN MPAVKAIIYQ YIEEIYHRIP NSDPSSSKTK 360
QVISKIRTQN LPNCQLISRS HYSPIYLSFI MLLAALSWQY LSTLSQVTED YVQREH 416 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004310; F:farnesyl-diphosphate farnesyltransferase activity; IEA:EC.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0051996; F:squalene synthase activity; IEA:EC.
 GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
 GO:0045338; P:farnesyl diphosphate metabolic process; IEA:Compara.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR002060; Squ/phyt_synthse.
 IPR006449; Squal_synth.
 IPR019845; Squalene/phytoene_synthase_CS.
 IPR008949; Terpenoid_synth. 
Pfam
 PF00494; SQS_PSY 
SMART
  
PROSITE
 PS01044; SQUALEN_PHYTOEN_SYN_1
 PS01045; SQUALEN_PHYTOEN_SYN_2 
PRINTS