CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Tns1 
Protein Synonyms/Alias
  
Gene Name
 Tns1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
324MKRFYEDKIVPIGQPubiquitination[1]
1733RDPTDESKDSSGPANubiquitination[1]
1841TEGGAPAKLFGFVARubiquitination[1]
1887VMLSAGQKR******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1888 AA 
Protein Sequence
MGCTVSLVCC EALEPLPSCG PQPPGTPPGP ARPERCEPGG AAPDPRRRLL LQPEDLEAPK 60
THHFKVKAFK KVKPCGICRQ AITREGCVCK VCSFSCHRKC QAKVAAPCVP PSSHELVPIT 120
TETVPKNVVD VGEGDCRVGS SPKNLEEGGS MRVSPSIQPQ PQSQPTSLSR NTSVSRAMED 180
SCELDLVYVT ERIIAVSFPS TANEENFRSN LREVAQMLKS KHGGNYLLFN LSEQRPDITK 240
LHAKVLEFGW PDLHTPALEK ICSVCKAMDT WLNADPHNVV VLHNKGNRGR IGVVIAAYLH 300
YSNISASADQ ALDRFAMKRF YEDKIVPIGQ PSQRRYVHYF SGLLSGSIKM NNKPLFLHHV 360
IMHGIPNFES KGGCRPFLRI YQAMQPVYTS GIYNIPGDSQ ASICITIEPG LLLKGDILLK 420
CYHKKFRSPA RDVIFRVQFH TCAIHDLGVV FGKEDLDEAF KDDRFPDYGK VEFVFSYGPE 480
KIQGMEHLEN GPSVSVDYNT SDPLIRWDSY DNFSGHREDG MEEVVGHTQG PLDGSLYAKV 540
KKKDSLNGSS GPVTTARPAL SATPNHVEHT LSVSSDSGNS TASTKTDKTD EPVSGATTAP 600
AALSPQEKKE LDRLLSGFGV DREKQGAMYR AQQLRSHPGG GPTVPSPGRH IVPAQVHVNG 660
GALASERETD ILDDELPIQD GQSGGSMGTL SSLDGVTNTS ESGYPETLSP LTNGLDKPYS 720
TEPVLNGGGY PYEAANRVIP VHSSHSAPIR PSYSAQEGLA GYQREGPHPA WSQQVTSAHC 780
GCDPSGLFRS QSFPDVEPQL PQAPTRGGSS REAVQRGLNS WQQQQPHPPP RQQERSPLQS 840
LARSKPSPQL SAETPVAALP EFPRAASQQE IEQSIETLNM LMLDLEPASA AAPLHKSQSV 900
PGAWPGASPL SSQPLLGSSR QSHPLTQSRS GYIPSGHSLG TPELVSSGRP YSPYDYQLHP 960
AGSNQSFHPK SPASSTFLPS PHSSAGPQEP PASLPGLIAQ PQLPPKETTS DPSRTPEEEP 1020
LNLEGLVAHR VAGVQARERQ PAEPPGPLRR RAASDGQYEN QSPEATSPRS PGVRSPVQCV 1080
SPELALTIAL NPGGRPKEPH LHSYKEAFEE MEGTSPSSPP HSVARSPPGL AKTPLSALGL 1140
KPHNPADILL HPTGVARRLI QPEEDEGEEV TKPPEEPRSY VESVARTAVA GPRAQDVEPK 1200
SFSAPAAHAY GHETPLRNGT PGGSFVSPSP LSTSSPILSA DSTSVGSFPS VVSSDQGPRT 1260
PFQPMLDSSI RSGSLGQPSP AALSYQSSSP VPVGGSSYNS PDYSLQPFSS SPESQGQPQY 1320
SAASVHMVPG SPQARHRTVG TNTPPSPGFG RRAVNPTMAA PGSPSLSHRQ VMGPSGPGFH 1380
GNVVSGHPAS AATTPGSPSL GRHPVGSHQV PGLHSSVVTT PGSPSLGRHP GAHQGNLASS 1440
LHSNAVISPG SPSLGRHLGG SGSVVPGSPS LDRHAAYGGY STPEDRRPTL SRQSSASGYQ 1500
APSTPSFPVS PAYYPGLSSP ATSPSPDSAA FRQGSPTPAL PEKRRMSVGD RAGSLPNYAT 1560
INGKVSSSPV ANGMASGSST VSFSHTLPDF SKYSMPDNSP ETRAKVKFVQ DTSKYWYKPE 1620
ISREQAIALL KDQEPGAFII RDSHSFRGAY GLAMKVSSPP PTITQQGKKG DMTHELVRHF 1680
LIETGPRGVK LKGCPNEPNF GSLSALVYQH SVIPLALPCK LVIPSRDPTD ESKDSSGPAN 1740
STTDLLKQGA ACNVLFVNSV DMESLTGPQA ISKATSETLA ADPTPAATIV HFKVSAQGIT 1800
LTDNQRKLFF RRHYPLNTVT FCDLDPQERK WMKTEGGAPA KLFGFVARKQ GSTTDNACHL 1860
FAELDPNQPA SAIVNFVSKV MLSAGQKR 1888 
Gene Ontology
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0003779; F:actin binding; TAS:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007044; P:cell-substrate junction assembly; IMP:MGI.
 GO:0010761; P:fibroblast migration; IMP:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR011993; PH_like_dom.
 IPR014019; Phosphatase_tensin-typ.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR013625; PTB.
 IPR006020; PTyr_interaction_dom.
 IPR000980; SH2.
 IPR014020; Tensin_phosphatase_C2-dom. 
Pfam
 PF08416; PTB
 PF10409; PTEN_C2
 PF00017; SH2 
SMART
 SM00109; C1
 SM00462; PTB
 SM00252; SH2 
PROSITE
 PS51182; C2_TENSIN
 PS51181; PPASE_TENSIN
 PS50001; SH2
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS