CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038547
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prolyl 4-hydroxylase subunit alpha-1 
Protein Synonyms/Alias
  
Gene Name
 P4ha1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
43KDLVTSLKDYIKAEEacetylation[1]
52YIKAEEDKLEQIKKWacetylation[2]
62QIKKWAEKLDRLTSTacetylation[1]
219LCRGEGIKMTPRRQKacetylation[2]
219LCRGEGIKMTPRRQKsuccinylation[2]
240HDGNRNPKFILAPAKacetylation[1]
273DAEIEIVKDLAKPRLacetylation[1]
302TAQYRVSKSAWLSGYacetylation[1]
430CPVLVGNKWVSNKWLacetylation[1]
435GNKWVSNKWLHERGQacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MIWVVLMMAI LLPQSLAHPG FFTSIGQMTD LIHNEKDLVT SLKDYIKAEE DKLEQIKKWA 60
EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LILKDMSDGF ISNLTIQRQY 120
FPNDEDQVGA AKALFRLQDT YNLDTNTISK GNLPDPEHQR ANGNLVYFEY IMSKEKDANK 180
SASGDQSDQK TAPKKKGIAV DYLPERQKYE MLCRGEGIKM TPRRQKRLFC RYHDGNRNPK 240
FILAPAKQED EWDKPRIIRF HDIISDAEIE IVKDLAKPRL SRATVHDPET GKLTTAQYRV 300
SKSAWLSGYE DPVVSRINMR IQDLTGLDVS TAEELQVANY GVGGQYEPHF DFARKDEPDA 360
FRELGTGNRI ATWLFYMSDV SAGGATVFPE VGASVWPKKG TAVFWYNLFA SGEGDYSTRH 420
AACPVLVGNK WVSNKWLHER GQEFRRPCTL SELE 454 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
 GO:0004656; F:procollagen-proline 4-dioxygenase activity; IDA:MGI.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0018401; P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline; IDA:MGI. 
Interpro
 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR006620; Pro_4_hyd_alph.
 IPR013547; Pro_4_hyd_alph_N.
 IPR011990; TPR-like_helical. 
Pfam
 PF03171; 2OG-FeII_Oxy
 PF08336; P4Ha_N 
SMART
 SM00702; P4Hc 
PROSITE
 PS51471; FE2OG_OXY 
PRINTS