UniProt Accession

 VA0D1_MOUSE; P51863; Q54A57; Q9QWJ2 

Genbank Protein ID

 U13840; U21549; AB088408; AK083372; AK171515 

Genbank Nucleotide ID

 AAC83085.1; AAA92288.1; BAC57954.1; BAC38889.1; BAE42500.1 

Protein Name

 V-type proton ATPase subunit d 1 

Protein Synonyms/Alias

 V-ATPase subunit d 1; P39; Physophilin; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; Vacuolar proton pump subunit d 1 

Gene Name

 Atp6v0d1 

Gene Synonyms/Alias

 Atp6d 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
73	TVSVIDDKLKEKMVV	ubiquitination	[1]
187	IIRNTLYKAYLESFY	ubiquitination	[1]
265	ADDYEQVKNVADYYP	ubiquitination	[1]
275	ADYYPEYKLLFEGAG	ubiquitination	[1]
288	AGSNPGDKTLEDRFF	ubiquitination	[1]
343	IAQRHRAKIDNYIPI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). 

Sequence Annotation

 MOD_RES 270 270 Phosphotyrosine.
 MOD_RES 283 283 Phosphoserine.  

Keyword

 Cilium biogenesis/degradation; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 351 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IDA:MGI.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042384; P:cilium assembly; ISS:UniProtKB. 

Interpro

 IPR002843; ATPase_V0-cplx_csu/dsu.
 IPR016727; ATPase_V0-cplx_dsu. 

Pfam

 PF01992; vATP-synt_AC39 

SMART

  

PROSITE

  

PRINTS