UniProt Accession

 APC11_HUMAN; Q9NYG5; A8MTT2; B7ZW64; Q502X9; Q9BW64; Q9P0R2 

Genbank Protein ID

 AF247565; AF247789; AF151048; AC145207; BC000607; BC066308; BC095454; BC104641; BC171892; BC171898; BC171899; BC171900 

Genbank Nucleotide ID

 AAF65816.1; AAL95694.1; AAF36134.1; AAH00607.2; AAH66308.1; AAH95454.1; AAI04642.1; AAI71892.1; AAI71898.1; AAI71899.1; AAI71900.1 

Protein Name

 Anaphase-promoting complex subunit 11 

Protein Synonyms/Alias

 APC11; Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger protein 

Gene Name

 ANAPC11 

Gene Synonyms/Alias

 HSPC214 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	PMCRQEWKFKE****	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. 

Sequence Annotation

 ZN_FING 34 77 RING-type.
 METAL 23 23 Zinc 1 (By similarity).
 METAL 26 26 Zinc 1 (By similarity).
 METAL 34 34 Zinc 3 (By similarity).
 METAL 37 37 Zinc 3 (By similarity).
 METAL 44 44 Zinc 3 (By similarity).
 METAL 51 51 Zinc 2 (By similarity).
 METAL 53 53 Zinc 2 (By similarity).
 METAL 56 56 Zinc 1 (By similarity).
 METAL 58 58 Zinc 3 (By similarity).
 METAL 59 59 Zinc 1 (By similarity).
 METAL 73 73 Zinc 2 (By similarity).
 METAL 76 76 Zinc 2 (By similarity).  

Keyword

 Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Metal-binding; Mitosis; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; TAS:UniProtKB.
 GO:0007094; P:mitotic spindle assembly checkpoint; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB. 

Interpro

 IPR024991; Apc11.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF12861; zf-Apc11 

SMART

 SM00184; RING 

PROSITE

 PS50089; ZF_RING_2 

PRINTS