CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase, H3 lysine-79-specific 
Protein Synonyms/Alias
  
Gene Name
 DOT1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57GGRIVSSKPFAPLNFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1210 AA 
Protein Sequence
XEYTLERGDF LSEEWRERIA NTSVIFVNNF AFGPEVDHQL KERFANMKEG GRIVSSKPFA 60
PLNFRINSRN LSDIGTIMRV VELSPLKGSV SWTGKPVSYY LHTIDRTILE NYFSSLKNPK 120
LREEQEAARR RQQRESKSNA ATPTKGPEGK VAGPADAPMD SGAEEEKAGA ATVKKPSPSK 180
ARKKKLNKKG RKMAGRKRGR PKKMNTANPE RKPKKNQTAL DALHAQTVSQ TAASSPQDAY 240
RSPHSPFYQL PPSVQRHSPN PLLVAPTPPA LQKLLESFKI QYLQFLAYTK TPQYKASLQE 300
LLGQEKEKNA QLLGAAQQLL SHCQAQKEEI RRLFQQKLDE LGVKALTYND LIQAQKEISA 360
HNQQLREQSE QLEQDNRALR GQSLQLLKAR CEELQLDWAT LSLEKLLKEK QALKSQISEK 420
QRHCLELQIS IVELEKSQRQ QELLQLKSCV PPDDALSLHL RGKGALGREL EPDASRLHLE 480
LDCTKFSLPH LSSMSPELSM NGQAAGYELC GVLSRPSSKQ NTPQYLASPL DQEVVPCTPS 540
HVGRPRLEKL SGLAAPDYTR LSPAKIVLRR HLSQDHTVPG RPAASELHSR AEHTKENGLP 600
YQSPSVPGSM KLSPQDPRPL SPGALQLAGE KSSEKGLRER AYGSSGELIT SLPISIPLST 660
VQPNKLPVSI PLASVVLPSR AERARSTPSP VLQPRDPSST LEKQIGANAH GAGSRSLALA 720
PAGFSYAGSV AISGALAGSP ASLTPGAEPA TLDESSSSGS LFATVGSRSS TPQHPLLLAQ 780
PRNSLPASPA HQLSSSPRLG GAAQGPLPEA SKGDLPSDSG FSDPESEAKR RIVFTITTGA 840
GSAKQSPSSK HSPLTASARG DCVPSHGQDS RRRGRRKRAS AGTPSLSAGV SPKRRALPSV 900
AGLFTQPSGS PLNLNSMVSN INQPLEITAI SSPETSLKSS PVPYQDHDQP PVLKKERPLS 960
QTNGAHYSPL TSDEEPGSED EPSSARIERK IATISLESKS PPKTLENGVF NHAVPSASAH 1020
PFGARVGRGA ACGSATLGPS PLQAAASASA SSFQAPASVE TRPPPPPPPP PPPLPPPAHL 1080
GRSPAGPPVL HAPPPPNAAL PPPPTLLASN PEPALLQSLA SLPPNQAFLP PTSAASLPPA 1140
NASLSIKLTS LPHKGARPSF TVHHQPLPRL ALAQAAPGIP QASATGPSAV WVSLGMPPPY 1200
AAHLSGVKPR 1210 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
 GO:0034968; P:histone lysine methylation; IEA:GOC. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR013110; DOT1.
 IPR025789; Histone_H3-K79_MeTrfase.
 IPR021169; Histone_H3-K79_MeTrfase_met. 
Pfam
 PF08123; DOT1 
SMART
 SM00384; AT_hook 
PROSITE
 PS51569; DOT1 
PRINTS