UniProt Accession

 H6ST1_HUMAN; O60243; B4DEP2; B4DJ29; Q53SL2; Q9BVI1 

Genbank Protein ID

 AB006179; AK293724; AK295898; AC017079; BC001196; BC096239; BC096240; BC099638; BC099639 

Genbank Nucleotide ID

 BAA25760.1; BAG57153.1; BAG58691.1; AAY14736.1; AAH01196.1; AAH96239.4; AAH96240.4; AAH99638.4; AAH99639.4 

Protein Name

 Heparan-sulfate 6-O-sulfotransferase 1 

Protein Synonyms/Alias

 HS6ST-1 

Gene Name

 HS6ST1 

Gene Synonyms/Alias

 HS6ST 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
123	CDCRPGQKKCTCYRP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. 

Sequence Annotation

 REGION 96 102 5'-phosphosulfate-binding (Potential).
 REGION 185 193 3'-phosphate binding (Potential).
 CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
 CARBOHYD 320 320 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Disease mutation; Glycoprotein; Hypogonadotropic hypogonadism; Kallmann syndrome; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 411 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0008146; F:sulfotransferase activity; TAS:ProtInc.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
 GO:0015015; P:heparan sulfate proteoglycan biosynthetic process, enzymatic modification; TAS:ProtInc.
 GO:0060716; P:labyrinthine layer blood vessel development; IEA:Compara.
 GO:0048286; P:lung alveolus development; IEA:Compara.
 GO:0048666; P:neuron development; IMP:UniProtKB. 

Interpro

 IPR010635; Heparan_SO4-6-sulfoTrfase.
 IPR027417; P-loop_NTPase.
 IPR005331; Sulfotransferase. 

Pfam

 PF03567; Sulfotransfer_2 

SMART

  

PROSITE

  

PRINTS