CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025174
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 Rhoa 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
118PIILVGNKKDLRNDEubiquitination[1]
135RRELAKMKQEPVKPEubiquitination[1]
162GYMECSAKTKDGVREubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 GTP-binding; Membrane; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 193 AA 
Protein Sequence
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEIYVPTVFE NYVADIEVDG KQVELALWDT 60
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 120
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ 180
ARRGKKKSGC LIL 193 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0032587; C:ruffle membrane; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:MGI.
 GO:0030521; P:androgen receptor signaling pathway; IDA:MGI.
 GO:0000902; P:cell morphogenesis; IGI:MGI.
 GO:0007160; P:cell-matrix adhesion; IDA:MGI.
 GO:0021795; P:cerebral cortex cell migration; IMP:MGI.
 GO:0021861; P:forebrain radial glial cell differentiation; IMP:MGI.
 GO:0007229; P:integrin-mediated signaling pathway; TAS:MGI.
 GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; IDA:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0045666; P:positive regulation of neuron differentiation; ISO:MGI.
 GO:0071803; P:positive regulation of podosome assembly; IGI:MGI.
 GO:0051496; P:positive regulation of stress fiber assembly; ISO:MGI.
 GO:2000177; P:regulation of neural precursor cell proliferation; IMP:MGI.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0007266; P:Rho protein signal transduction; TAS:MGI.
 GO:0007519; P:skeletal muscle tissue development; IDA:MGI.
 GO:0043149; P:stress fiber assembly; IDA:MGI. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 
Pfam
 PF00071; Ras 
SMART
 SM00174; RHO 
PROSITE
 PS51420; RHO 
PRINTS
 PR00449; RASTRNSFRMNG.