CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034369
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Estradiol 17 beta-dehydrogenase 5 
Protein Synonyms/Alias
  
Gene Name
 Akr1c6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
22KIADGTVKREDIFYTubiquitination[1]
70IHFPMAMKPGENYLPubiquitination[1]
78PGENYLPKDENGKLIacetylation[2]
78PGENYLPKDENGKLIubiquitination[1]
102WEAMEKCKDAGLAKSubiquitination[1]
108CKDAGLAKSIGVSNFubiquitination[1]
122FNRRQLEKILKKPGLacetylation[3]
125RQLEKILKKPGLKYKubiquitination[1]
132KKPGLKYKPVCNQVEacetylation[2]
132KKPGLKYKPVCNQVEubiquitination[1]
148HPYLNQGKLLDFCRSubiquitination[1]
156LLDFCRSKDIVLVAYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 175 AA 
Protein Sequence
MYQNEKEVGL AIRSKIADGT VKREDIFYTS KVWCTFHRPE LVRVCLEQSL KQLQLDYVDL 60
YLIHFPMAMK PGENYLPKDE NGKLIYDAVD ICDTWEAMEK CKDAGLAKSI GVSNFNRRQL 120
EKILKKPGLK YKPVCNQVEC HPYLNQGKLL DFCRSKDIVL VAYSALGSHR EKQWV 175 
Gene Ontology
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IDA:MGI.
 GO:0008202; P:steroid metabolic process; IDA:MGI. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00062; ALDOKETO_REDUCTASE_2 
PRINTS
 PR00069; ALDKETRDTASE.