CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007114
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NADP] 
Protein Synonyms/Alias
 IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase 
Gene Name
 icd 
Gene Synonyms/Alias
 citC; BSU29130 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
59GEKKITWKEVYAGEKacetylation[1]
190ETSGIGIKPVSEEGTacetylation[1]
226VHKGNIMKFTEGAFKacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
  
Sequence Annotation
 NP_BIND 345 351 NADP (By similarity).
 METAL 311 311 Magnesium or manganese (By similarity).
 BINDING 95 95 NADP (By similarity).
 BINDING 96 96 Substrate.
 BINDING 104 104 Substrate.
 BINDING 106 106 Substrate.
 BINDING 110 110 Substrate.
 BINDING 120 120 Substrate (By similarity).
 BINDING 144 144 Substrate.
 BINDING 358 358 NADP; via amide nitrogen and carbonyl
 BINDING 397 397 NADP (By similarity).
 BINDING 401 401 NADP (By similarity).  
Keyword
 3D-structure; Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MAQGEKITVS NGVLNVPNNP IIPFIEGDGT GPDIWNAASK VLEAAVEKAY KGEKKITWKE 60
VYAGEKAYNK TGEWLPAETL DVIREYFIAI KGPLTTPVGG GIRSLNVALR QELDLFVCLR 120
PVRYFTGVPS PVKRPEDTDM VIFRENTEDI YAGIEYAKGS EEVQKLISFL QNELNVNKIR 180
FPETSGIGIK PVSEEGTSRL VRAAIDYAIE HGRKSVTLVH KGNIMKFTEG AFKNWGYELA 240
EKEYGDKVFT WAQYDRIAEE QGKDAANKAQ SEAEAAGKII IKDSIADIFL QQILTRPNEF 300
DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYETGHAI FEATHGTAPK YAGLDKVNPS 360
SVILSGVLLL EHLGWNEAAD LVIKSMEKTI ASKVVTYDFA RLMDGATEVK CSEFGEELIK 420
NMD 423 
Gene Ontology
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004439; Isocitrate_DH_NADP_dimer_prok.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS