UniProt Accession

 TACO1_HUMAN; Q9BSH4; B2RD21; Q8N3N6; Q9UI60 

Genbank Protein ID

 AK315375; CH471109; BC005049; BC007744; AL833861; AF090929 

Genbank Nucleotide ID

 BAG37768.1; EAW94304.1; AAH05049.1; AAH07744.1; CAD38719.1; AAF24044.1 

Protein Name

 Translational activator of cytochrome c oxidase 1 

Protein Synonyms/Alias

 Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase I 

Gene Name

 TACO1 

Gene Synonyms/Alias

 CCDC44; PRO0477 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
119	CRSKHMPKSTIETAL	acetylation	[1]
170	DIRHILNKNGGVMAV	ubiquitination	[2, 3]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1. 

Sequence Annotation

  

Keyword

 Activator; Coiled coil; Complete proteome; Leigh syndrome; Mitochondrion; Polymorphism; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 

Interpro

 IPR017856; Integrase_Zn-bd_dom-like_N.
 IPR002876; Transcrip_reg_TACO1-like.
 IPR026563; Transcrip_reg_TACO1-like_dom2.
 IPR026564; Transcrip_reg_TACO1-like_dom3. 

Pfam

 PF01709; Transcrip_reg 

SMART

  

PROSITE

  

PRINTS