CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036551
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BCL6 corepressor/retinoic acid receptor alpha fusion protein 
Protein Synonyms/Alias
  
Gene Name
 BCOR-RARA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1408ARRLIVNKNAGETLLubiquitination[1]
1587FFRRSIQKNMVYTCHubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; DNA-binding; Metal-binding; Nucleus; Receptor; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1931 AA 
Protein Sequence
MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 60
AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 120
EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 180
INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 240
GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 300
SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 360
YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 420
GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 480
EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 540
SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 600
PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 660
PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 720
GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 780
TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 840
SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 900
LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 960
KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQR AMMRFSELEM KEREGGHPAT 1020
KDSEMCKFSP ADWERLKGNQ DKKPKSVTLE EAIAEQNESE RCEYSVGNKH RDPFEAPEDK 1080
DLPVEKYFVE RQPVSEPPAD QVASDMPHSP TLRVDRKRKV SGDSSHTETT AEEVPEDPLL 1140
KAKRRRVSKG LHPKKQRHLL HLRERWEQQV SAADGKPGRQ SRKEVTQATQ PEAIPQGTNI 1200
TEEKPGRKRA EAKGNRSWSE ESLKPSDNEQ GLPVFSGSPP MKSLSSTSAG GKKQAQPSCA 1260
PASRPPAKQQ KIKENQKTDV LCADEEEDCQ AASLLQKYTD NSEKPSGKRL CKTKHLIPQE 1320
SRRGLPLTGE YYVENADGKV TVRRFRKRPE PSSDYDLSPA KQEPKPFDRL QQLLPASQST 1380
QLPCSSSPQE TTQSRPMPPE ARRLIVNKNA GETLLQRAAR LGYEEVVLYC LENKICDVNH 1440
RDNAGYCALH EACARGWLNI VRHLLEYGAD VNCSAQDGTR PLHDAVENDH LEIVRLLLSY 1500
GADPTLATYS GRTIMKMTHS ELMEKFLTAI ETQSSSSEEI VPSPPSPPPL PRIYKPCFVC 1560
QDKSSGYHYG VSACEGCKGF FRRSIQKNMV YTCHRDKNCI INKVTRNRCQ YCRLQKCFEV 1620
GMSKESVRND RNKKKKEVPK PECSESYTLT PEVGELIEKV RKAHQETFPA LCQLGKYTTN 1680
NSSEQRVSLD IDLWDKFSEL STKCIIKTVE FAKQLPGFTT LTIADQITLL KAACLDILIL 1740
RICTRYTPEQ DTMTFSDGLT LNRTQMHNAG FGPLTDLVFA FANQLLPLEM DDAETGLLSA 1800
ICLICGDRQD LEQPDRVDML QEPLLEALKV YVRKRRPSRP HMFPKMLMKI TDLRSISAKG 1860
AERVITLKME IPGSMPPLIQ EMLENSEGLD TLSGQPGGGG RDGGGLAPPP GSCSPSLSPS 1920
SNRSSPATHS P 1931 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003708; F:retinoic acid receptor activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR003078; Retinoic_acid_rcpt.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF12796; Ank_2
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00248; ANK
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR01292; RETNOICACIDR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.