| Tag | Content |
|---|
| CPLM ID | CPLM-000850 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytoplasmic protein NCK2 |
Protein Synonyms/Alias | Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta |
Gene Name | Nck2 |
Gene Synonyms/Alias | Grb4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 72 | GSLVKNLKDTLGLGK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling (By similarity). |
Sequence Annotation | DOMAIN 2 61 SH3 1.
DOMAIN 111 170 SH3 2.
DOMAIN 195 257 SH3 3.
DOMAIN 285 379 SH2.
MOD_RES 90 90 Phosphoserine (By similarity).
MOD_RES 110 110 Phosphotyrosine (By similarity).
MOD_RES 342 342 Phosphotyrosine. |
Keyword | Complete proteome; Cytoplasm; Endoplasmic reticulum; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 380 AA |
Protein Sequence | MTEEVIVIAK WDYTAQQDQE LDIRKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT RRKPSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF 120
AYVAEREDEL SLVKGSRVTV MEKCSDGWWR GSFNGQIGWF PSNYVLEEAD EAAAEAPSFL 180
SLRRGTALSN GQGARVLHVV QTLYPFSSVT EEELSFEKGE TMEVIEKPEN DPEWWKCKNA 240
RGQVGLVPKN YVVVLSDGPA LHPAHTPQIS YTGPSASGRF AGREWYYGNV TRHQAECALN 300
ERGVEGDFLI RDSESSPSDF SVSLKASGRN KHFKVQLVDS VYCIGQRRFH SMDELVEHYK 360
KAPIFTSEHG EKLYLVRALQ 380 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0012506; C:vesicle membrane; IDA:MGI. GO:0007015; P:actin filament organization; IMP:MGI. GO:0016477; P:cell migration; IMP:MGI. GO:0030032; P:lamellipodium assembly; IMP:MGI. GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara. GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |