| Tag | Content |
|---|
| CPLM ID | CPLM-014949 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Keratin, type I cytoskeletal 27 |
Protein Synonyms/Alias | Cytokeratin-27; CK-27; Keratin-27; K27; Type I inner root sheath-specific keratin-K25irs3; Type I keratin KA40 |
Gene Name | Krt27 |
Gene Synonyms/Alias | Ka40 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 358 | RTETEGQKLEYEQLL | acetylation | [1] | | 368 | YEQLLNVKAHLEKEI | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). |
Sequence Annotation | REGION 1 73 Head.
REGION 74 385 Rod.
REGION 74 109 Coil 1A.
REGION 110 131 Linker 1.
REGION 132 223 Coil 1B.
REGION 224 246 Linker 12.
REGION 247 385 Coil 2.
REGION 386 449 Tail. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Intermediate filament; Keratin; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 449 AA |
Protein Sequence | MSVRFSSASR RLGSVRLSSP GAALGAGNTC GVPGIGSGFS CAFGGSSLAG GLGMGGASCG 60
AFTVNEHGLL SGNEKVTMQN LNDRLASYLE NVQALEEANA DLEQKIKDWY EKFGPGSCRG 120
LDHDYSRYFP IIDDLRTQII SATAQNANIV LQNDNARLTA DDFRMKYENE LALHQSVDAD 180
INGLRRVLDE LTLCRTDLEV QLETLSEELA YLKKNHEEEM QALQCAAGGN VNVEMNAAPG 240
VDLTVLLNNM RAEYEALAEQ NRRDAEAWFQ EKSASLQQQI SDDAGATTSA RNELTEMKRT 300
LQTLEIELQS LLAMKHSLEC SLTETEGNYC TQLAQIQAQI SALEEQLHQV RTETEGQKLE 360
YEQLLNVKAH LEKEIETYCL LIGGDEGSCV KSKGQGGPGN QTKDSPKTAI VKTVVEELDP 420
RGKVLSSRVH TLEEKSTKVN NKNEQRIPS 449 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0031069; P:hair follicle morphogenesis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |