CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025414
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Sf3b2 
Protein Synonyms/Alias
 Splicing factor 3b, subunit 2 
Gene Name
 Sf3b2 
Gene Synonyms/Alias
 mCG_19856 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
165MQQEERAKQAAVLMEubiquitination[1]
181ERQQEIAKMGTAVPRubiquitination[1]
258KIPQALEKILQLKESacetylation[2, 3]
258KIPQALEKILQLKESubiquitination[1]
263LEKILQLKESRQEEMubiquitination[1]
377KRIFEAFKLTDDVKKubiquitination[1]
449RFTVAELKQLVARPDubiquitination[1]
469DVTAQDPKLLVHLKAubiquitination[1]
512FELPDFIKRTGIQEMubiquitination[1]
553KIDIDYQKLHDAFFKubiquitination[1]
587FETRLKEKKPGDLSDubiquitination[1]
853MVAEHAAKQKQKKRKphosphoglycerylation[4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 878 AA 
Protein Sequence
MAAEHPEPPK GELQLPPPPP PGHYGAWAAQ ELQARLAEIG APIQGSREEL VERLQTYTRQ 60
TGIVLNRPVL RGEDGDKAAP PPMSAQLSGI PMPPPPMGLP PLQPPPPPPP PPPGLGLGFP 120
MAHPPNLGPP PPLRVGEPVA LSEEERLKLA QQQAALLMQQ EERAKQAAVL MEQERQQEIA 180
KMGTAVPRPP QDMGQLGVRT PLGPRVAAPV GPVVPTPTVL PMGAPVPRPR GPPPPPGDEN 240
REMDDPSVGP KIPQALEKIL QLKESRQEEM NSQQEEEEME TDTRSSLGQS ASETEEDTVS 300
ISKKEKNRKR RNRKKKKKPQ RVRAASSESS GDREKDSGRS RGSDPPAADV EIEYVTEEPE 360
IYEPNFIFFK RIFEAFKLTD DVKKEKEKEP EKLDKMESSA VPKKKGFEEE HKDSDDDSSD 420
DEQEKKPEAP KLSKKKLRRM NRFTVAELKQ LVARPDVVEM HDVTAQDPKL LVHLKATRNS 480
VPVPRHWCFK RKYLQGKRGI EKPPFELPDF IKRTGIQEMR EALQEKEEQK TMKSKMREKV 540
RPKMGKIDID YQKLHDAFFK WQTKPKLTIH GDLYYEGKEF ETRLKEKKPG DLSDELRISL 600
GMPVGPNAHK VPPPWLIAMQ RYGPPPSYPN LKIPGLNSPI PESCSFGYHA GGWGKPPVDE 660
TGKPLYGDVF GTNAAEFQTK TEEEEIDRTP WGELEPSDEE SSEEEEEEES DEDKPDETGF 720
ITPADSGLIT PGGFSSVPAG METPELIELR KKKIEEAMDG SETPQLFTVL PEKRTATVGG 780
AMMGSTHIYD MSTVMSRKGP APELQGVEVA LAPEELELDP MAMTQKYEEH VREQQAQVEK 840
EDFSDMVAEH AAKQKQKKRK AQPQDSRGGS KKYKEFKF 878 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005689; C:U12-type spliceosomal complex; IEA:Compara.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR007180; DUF382.
 IPR006568; PSP.
 IPR003034; SAP_dom. 
Pfam
 PF04037; DUF382
 PF04046; PSP
 PF02037; SAP 
SMART
 SM00581; PSP
 SM00513; SAP 
PROSITE
 PS50800; SAP 
PRINTS