| Tag | Content |
|---|
| CPLM ID | CPLM-017491 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase ZNF645 |
Protein Synonyms/Alias | Zinc finger protein 645 |
Gene Name | ZNF645 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 3 | *****MNKMPAGEQE | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. |
Sequence Annotation | ZN_FING 57 97 RING-type.
ZN_FING 112 138 C2H2-type.
REGION 96 154 HYB domain. |
Keyword | Complete proteome; Cytoplasm; Ligase; Metal-binding; Polymorphism; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 425 AA |
Protein Sequence | MNKMPAGEQE CEYNKEGKYY SKGVKLVRKK KKIPGYRWGD IKINIIGEKD DLPIHFCDKC 60
DLPIKIYGRI IPCKHAFCYH CANLYDKVGY KVCPRCRYPV LRIEAHKRGS VFMCSIVQQC 120
KRTYLSQKSL QAHIKRRHKR ARKQVTSASL EKVRPHIAPP QTEISDIPKR LQDRDHLSYI 180
PPEQHTMVSL PSVQHMLQEQ HNQPHKDIQA PPPELSLSLP FPIQWETVSI FTRKHGNLTV 240
DHIQNNSDSG AKKPTPPDYY PECQSQPAVS SPHHIIPQKQ HYAPPPSPSS PVNHQMPYPP 300
QDVVTPNSVR SQVPALTTTY DPSSGYIIVK VPPDMNSPPL RAPQSQNGNP SASEFASHHY 360
NLNILPQFTE NQETLSPQFT QTDAMDHRRW PAWKRLSPCP PTRSPPPSTL HGRSHHSHQR 420
RHRRY 425 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |