UniProt Accession

 C9JEI7_HUMAN; C9JEI7 

Genbank Protein ID

 D87012 

Genbank Nucleotide ID

  

Protein Name

 DNA topoisomerase 3-beta-1 

Protein Synonyms/Alias

  

Gene Name

 TOP3B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	NPKLNMVKFLQVEGR	ubiquitination	[1, 2]
198	AFTRFQTKYFQGKYG	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0000793; C:condensed chromosome; IEA:Compara.
 GO:0003917; F:DNA topoisomerase type I activity; IEA:InterPro.
 GO:0007059; P:chromosome segregation; IEA:Compara.
 GO:0006265; P:DNA topological change; IEA:InterPro. 

Interpro

 IPR000380; Topo_IA.
 IPR003601; Topo_IA_2.
 IPR013497; Topo_IA_cen.
 IPR013824; Topo_IA_cen_sub1.
 IPR023405; Topo_IA_core_domain.
 IPR006171; Toprim_domain. 

Pfam

 PF01131; Topoisom_bac
 PF01751; Toprim 

SMART

 SM00436; TOP1Bc
 SM00493; TOPRIM 

PROSITE

  

PRINTS