CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017464
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 ZBTB2 
Gene Synonyms/Alias
 KIAA1483; ZNF437 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
388HMYIHTGKPFKCSTCacetylation[1]
505HPVLASIKKEQETVLsumoylation[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 24 89 BTB.
 ZN_FING 254 276 C2H2-type 1.
 ZN_FING 363 385 C2H2-type 2.
 ZN_FING 390 410 C2H2-type 3; atypical.
 ZN_FING 448 468 C2H2-type 4; atypical.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK MLFVHQTSEC 60
VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK FLHAYPLIQE ASLASQGAFS 120
HPDQVFPLAS SLYGIQIADH QLRQATKIAS APEKLGRDPR PQTSRISQEQ VPEASQLSQL 180
TSNLAQVNRT NMTPSDPLQT SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK 240
PSIMKRNGSF PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA 300
DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE QADQEREVKR 360
RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC RANQAARHVC LNQSIDTYTM 420
VDKQTLELCT FEEGSQMDNM LVQTNKPYKC NLCDKTFSTP NEVVKHSCQN QNSDVFALDE 480
GRSILLGSGD SEVTEPDHPV LASIKKEQET VLLD 514 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB
 PF00096; zf-C2H2 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS