UniProt Accession

 CYBP_PONAB; Q5R6Z8 

Genbank Protein ID

 CR860325 

Genbank Nucleotide ID

 CAH92462.1 

Protein Name

 Calcyclin-binding protein 

Protein Synonyms/Alias

 CacyBP 

Gene Name

 CACYBP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 

NCBI Taxa ID

 9601 

Lysine Modification

Position	Peptide	Type	References
85	YGWDQSDKFVKIYIT	ubiquitination	[1, 2]
118	RSFDLLVKNLNGKSY	ubiquitination	[1, 2]
123	LVKNLNGKSYSMIVN	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). 

Sequence Annotation

 DOMAIN 73 167 CS.
 DOMAIN 168 228 SGS.
 REGION 2 80 Interaction with SIAH1 (By similarity).
 REGION 73 228 Interaction with SKP1 (By similarity).
 REGION 154 228 Interaction with S100A6 (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 19 19 N6-acetyllysine (By similarity).
 MOD_RES 85 85 N6-acetyllysine (By similarity).
 MOD_RES 118 118 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007699; SGS.
 IPR015120; Siah-Interact_N. 

Pfam

 PF04969; CS
 PF05002; SGS
 PF09032; Siah-Interact_N 

SMART

  

PROSITE

 PS51203; CS
 PS51048; SGS 

PRINTS