CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-044307
UniProt Accession
J3KMZ9_HUMAN
;
J3KMZ9
Genbank Protein ID
AC011485
Genbank Nucleotide ID
Protein Name
Low-density lipoprotein receptor
Protein Synonyms/Alias
Gene Name
LDLR
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
915
FDNPVYQ
K
TTEDEVH
ubiquitination
[1]
Reference
[1] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [
PMID: 21963094
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Disulfide bond; EGF-like domain; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
945 AA
Protein Sequence
XGRPGVPPRF LSQRRRQVPG PRSRLRDIHE SPSVILGPPG EVPGFRCALW RHLRPHLVLG 60
GALAPPAPIK FTEGPPATLK ASVPYEVETL PQNLPAPPWS AAEIFSHVGD RCERNEFQCQ 120
DGKCISYKWV CDGSAECQDG SDESQETCLS VTCKSGDFSC GGRVNRCIPQ FWRCDGQVDC 180
DNGSDEQGCP PKTCSQDEFR CHDGKCISRQ FVCDSDRDCL DGSDEASCPV LTCGPASFQC 240
NSSTCIPQLW ACDNDPDCED GSDEWPQRCR GLYVFQGDSS PCSAFEFHCL SGECIHSSWR 300
CDGGPDCKDK SDEENCAVAT CRPDEFQCSD GNCIHGSRQC DREYDCKDMS DEVGCVNVTL 360
CEGPNKFKCH SGECITLDKV CNMARDCRDW SDEPIKECGT NECLDNNGGC SHVCNDLKIG 420
YECLCPDGFQ LVAQRRCEDI DECQDPDTCS QLCVNLEGGY KCQCEEGFQL DPHTKACKAV 480
GSIAYLFFTN RHEVRKMTLD RSEYTSLIPN LRNVVALDTE VASNRIYWSD LSQRMICSTQ 540
LDRAHGVSSY DTVISRDIQA PDGLAVDWIH SNIYWTDSVL GTVSVADTKG VKRKTLFREN 600
GSKPRAIVVD PVHGFMYWTD WGTPAKIKKG GLNGVDIYSL VTENIQWPNG ITLDLLSGRL 660
YWVDSKLHSI SSIDVNGGNR KTILEDEKRL AHPFSLAVFE DKVFWTDIIN EAIFSANRLT 720
GSDVNLLAEN LLSPEDMVLF HNLTQPRGVN WCERTTLSNG GCQYLCLPAP QINPHSPKFT 780
CACPDGMLLA RDMRSCLTEA EAAVATQETS TVRLKVSSTA VRTQHTTTRP VPDTSRLPGA 840
TPGLTTVEIV TMSHQALGDV AGRGNEKKPS SVRALSIVLP IVLLVFLCLG VFLLWKNWRL 900
KNINSINFDN PVYQKTTEDE VHICHNQDGY SYPSRQMVSL EDDVA 945
Gene Ontology
GO:0016021
; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005509
; F:calcium ion binding; IEA:InterPro.
Interpro
IPR011042
; 6-blade_b-propeller_TolB-like.
IPR000742
; EG-like_dom.
IPR001881
; EGF-like_Ca-bd.
IPR013032
; EGF-like_CS.
IPR000152
; EGF-type_Asp/Asn_hydroxyl_site.
IPR018097
; EGF_Ca-bd_CS.
IPR009030
; Growth_fac_rcpt_N_dom.
IPR023415
; LDLR_class-A_CS.
IPR000033
; LDLR_classB_rpt.
IPR002172
; LDrepeatLR_classA_rpt.
Pfam
PF07645
; EGF_CA
PF00057
; Ldl_recept_a
PF00058
; Ldl_recept_b
SMART
SM00181
; EGF
SM00179
; EGF_CA
SM00192
; LDLa
SM00135
; LY
PROSITE
PS00010
; ASX_HYDROXYL
PS01186
; EGF_2
PS50026
; EGF_3
PS01187
; EGF_CA
PS01209
; LDLRA_1
PS50068
; LDLRA_2
PS51120
; LDLRB
PRINTS