UniProt Accession

 ARGI1_MOUSE; Q61176; Q3TB74; Q3UEL0; Q4FK78; Q80VI4 

Genbank Protein ID

 U51805; AK149471; AK171417; CT010173; BC013341; BC050005 

Genbank Nucleotide ID

 AAA98611.1; BAE28901.1; BAE42440.1; CAJ18381.1; AAH13341.1; AAH50005.2 

Protein Name

 Arginase-1 

Protein Synonyms/Alias

 Liver-type arginase; Type I arginase 

Gene Name

 Arg1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MSSKPKSLEIIGA	ubiquitination	[1]
17	IIGAPFSKGQPRGGV	acetylation	[2, 3, 4]
17	IIGAPFSKGQPRGGV	succinylation	[4]
17	IIGAPFSKGQPRGGV	ubiquitination	[1]
26	QPRGGVEKGPAALRK	acetylation	[3, 5, 6]
26	QPRGGVEKGPAALRK	ubiquitination	[1]
39	RKAGLLEKLKETEYD	acetylation	[4, 5, 6]
39	RKAGLLEKLKETEYD	succinylation	[4]
39	RKAGLLEKLKETEYD	ubiquitination	[1]
41	AGLLEKLKETEYDVR	acetylation	[2, 3, 4, 5]
41	AGLLEKLKETEYDVR	succinylation	[4]
41	AGLLEKLKETEYDVR	ubiquitination	[1]
68	DSSFQIVKNPRSVGK	ubiquitination	[1]
75	KNPRSVGKANEELAG	acetylation	[4]
75	KNPRSVGKANEELAG	succinylation	[4]
75	KNPRSVGKANEELAG	ubiquitination	[1]
89	GVVAEVQKNGRVSVV	acetylation	[3, 5, 6]
89	GVVAEVQKNGRVSVV	ubiquitination	[1]
153	SFLLKELKGKFPDVP	ubiquitination	[1]
155	LLKELKGKFPDVPGF	acetylation	[3, 5]
155	LLKELKGKFPDVPGF	ubiquitination	[1]
191	PGEHYIIKTLGIKYF	acetylation	[3, 5]
191	PGEHYIIKTLGIKYF	ubiquitination	[1]
196	IIKTLGIKYFSMTEV	ubiquitination	[1]
205	FSMTEVDKLGIGKVM	ubiquitination	[1]
284	EVNPTLGKTAEEVKS	acetylation	[3]
284	EVNPTLGKTAEEVKS	ubiquitination	[1]
313	TQREGNHKPGTDYLK	acetylation	[5]
313	TQREGNHKPGTDYLK	ubiquitination	[1]
320	KPGTDYLKPPK****	acetylation	[2, 3, 5, 6]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

 REGION 126 130 Substrate binding (By similarity).
 REGION 137 139 Substrate binding (By similarity).
 METAL 101 101 Manganese 1 (By similarity).
 METAL 124 124 Manganese 1 (By similarity).
 METAL 124 124 Manganese 2 (By similarity).
 METAL 126 126 Manganese 2 (By similarity).
 METAL 128 128 Manganese 1 (By similarity).
 METAL 232 232 Manganese 1 (By similarity).
 METAL 232 232 Manganese 2 (By similarity).
 METAL 234 234 Manganese 2 (By similarity).
 BINDING 183 183 Substrate (By similarity).
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 230 230 Phosphoserine.  

Keyword

 Arginine metabolism; Complete proteome; Cytoplasm; Hydrolase; Manganese; Metal-binding; Phosphoprotein; Reference proteome; Urea cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0004053; F:arginase activity; IDA:MGI.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Compara.
 GO:0071377; P:cellular response to glucagon stimulus; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0032964; P:collagen biosynthetic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0060056; P:mammary gland involution; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0070207; P:protein homotrimerization; IEA:Compara.
 GO:0010963; P:regulation of L-arginine import; IEA:Compara.
 GO:0014075; P:response to amine stimulus; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009635; P:response to herbicide; IEA:Compara.
 GO:0010042; P:response to manganese ion; IEA:Compara.
 GO:0051597; P:response to methylmercury; IEA:Compara.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0033189; P:response to vitamin A; IEA:Compara.
 GO:0033197; P:response to vitamin E; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway. 

Interpro

 IPR014033; Arginase.
 IPR006035; Ureohydrolase.
 IPR023696; Ureohydrolase_domain.
 IPR020855; Ureohydrolase_Mn_BS. 

Pfam

 PF00491; Arginase 

SMART

  

PROSITE

 PS01053; ARGINASE_1
 PS51409; ARGINASE_2 

PRINTS

 PR00116; ARGINASE.