| Tag | Content |
|---|
| CPLM ID | CPLM-003528 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Na(+)/H(+) antiporter NhaB |
Protein Synonyms/Alias | Sodium/proton antiporter NhaB |
Gene Name | nhaB |
Gene Synonyms/Alias | b1186; JW1175 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 186 | QDDSHIDKHYKVVLE | acetylation | [1] | | 189 | SHIDKHYKVVLEQFR | acetylation | [1] | | 275 | YGETLPEKVREVLQQ | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Has a high affinity for sodium, but can also transport lithium. Activity is weakly pH-dependent. Essential for regulation of intracellular pH under alkaline conditions. |
Sequence Annotation | |
Keyword | Antiport; Cell inner membrane; Cell membrane; Complete proteome; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 513 AA |
Protein Sequence | MEISWGRALW RNFLGQSPDW YKLALIIFLI VNPLIFLISP FVAGWLLVAE FIFTLAMALK 60
CYPLLPGGLL AIEAVFIGMT SAEHVREEVA ANLEVLLLLM FMVAGIYFMK QLLLFIFTRL 120
LLSIRSKMLL SLSFCVAAAF LSAFLDALTV VAVVISVAVG FYGIYHRVAS SRTEDTDLQD 180
DSHIDKHYKV VLEQFRGFLR SLMMHAGVGT ALGGVMTMVG EPQNLIIAKA AGWHFGDFFL 240
RMSPVTVPVL ICGLLTCLLV EKLRWFGYGE TLPEKVREVL QQFDDQSRHQ RTRQDKIRLI 300
VQAIIGVWLV TALALHLAEV GLIGLSVIIL ATSLTGVTDE HAIGKAFTES LPFTALLTVF 360
FSVVAVIIDQ QLFSPIIQFV LQASEHAQLS LFYIFNGLLS SISDNVFVGT IYINEAKAAM 420
ESGAITLKQY ELLAVAINTG TNLPSVATPN GQAAFLFLLT SALAPLIRLS YGRMVWMALP 480
YTLVLTLVGL LCVEFTLAPV TEWFMQMGWI ATL 513 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015385; F:sodium:hydrogen antiporter activity; IDA:EcoliWiki. GO:0006883; P:cellular sodium ion homeostasis; IGI:EcoCyc. GO:0051452; P:intracellular pH reduction; IMP:EcoCyc. GO:0010226; P:response to lithium ion; IGI:EcoliWiki. |
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Pfam | |
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PRINTS | |