UniProt Accession

 RFOX2_MOUSE; Q8BP71; Q0R5Z7; Q0R5Z8; Q0VH84; Q537D4; Q537D5; Q8BRG0; Q8R2T5; Q8VI62; Q923W8 

Genbank Protein ID

 AF387322; AY659951; AY659952; AY659953; AF229055; AY904025; DQ017388; DQ017389; AK044929; AK077594; BC002124; BC027263 

Genbank Nucleotide ID

 AAK64287.1; AAV74334.1; AAV74335.1; AAV74336.1; AAL71902.1; AAX84842.1; AAY78494.1; AAY78495.1; BAC32147.1; BAC36885.1; AAH02124.1; AAH27263.1 

Protein Name

 RNA binding protein fox-1 homolog 2 

Protein Synonyms/Alias

 Fox-1 homolog B; Fox-1 homolog Fxh; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9 

Gene Name

 Rbfox2 

Gene Synonyms/Alias

 Fox2; Fxh; Hrnbp2; Rbm9 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
238	DADRAREKLHGTVVE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). 

Sequence Annotation

 DOMAIN 180 256 RRM.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 449 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003729; F:mRNA binding; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0048813; P:dendrite morphogenesis; IMP:MGI.
 GO:0030520; P:intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.
 GO:0021942; P:radial glia guided migration of Purkinje cell; IMP:MGI.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:BHF-UCL.
 GO:0010724; P:regulation of definitive erythrocyte differentiation; IDA:BHF-UCL.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR025670; Fox-1_C_dom.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR017325; RNA-bd_Fox-1.
 IPR000504; RRM_dom. 

Pfam

 PF12414; Fox-1_C
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS