UniProt Accession

 GSTM2_MOUSE; P15626 

Genbank Protein ID

 J04696; AF319526; BC037068 

Genbank Nucleotide ID

 AAA37706.1; AAK28508.1; AAH37068.1 

Protein Name

 Glutathione S-transferase Mu 2 

Protein Synonyms/Alias

 GST 5-5; GST class-mu 2; Glutathione S-transferase pmGT2 

Gene Name

 Gstm2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
31	TDTSYEDKKYTMGDA	ubiquitination	[1]
32	DTSYEDKKYTMGDAP	acetylation	[2]
50	RSQWLSEKFKLGLDF	ubiquitination	[1]
52	QWLSEKFKLGLDFPN	ubiquitination	[1]
83	ILRYLARKHNLCGET	ubiquitination	[1]
144	LYSEFLGKQPWFAGN	ubiquitination	[1]
173	QHRIFEPKCLDAFPN	acetylation	[3]
206	KSSRFLSKPIFAKMA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 2 88 GST N-terminal.
 DOMAIN 90 208 GST C-terminal.
 REGION 7 8 Glutathione binding (By similarity).
 REGION 46 50 Glutathione binding (By similarity).
 REGION 59 60 Glutathione binding (By similarity).
 REGION 72 73 Glutathione binding (By similarity).
 BINDING 116 116 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004364; F:glutathione transferase activity; IDA:MGI.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01267; GSTRNSFRASEM.