| Tag | Content |
|---|
| CPLM ID | CPLM-009973 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-methylacyl-CoA racemase |
Protein Synonyms/Alias | 2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase |
Gene Name | Amacr |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 268 | IEDWPEMKKKFADVF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Has a role in drug metabolism as well as probably in lipid metabolism. The 2- arylpropionic acid (2-APA's) derivatives, including ibuprofen, are the most widely used anti-inflammatory analgesic cyclooxygenase inhibitors. The (-)-R-enantiomer, which is inactive in terms of cyclooxygenase inhibition, is epimerized in vivo via this enzyme to the cyclooxygenase-inhibiting (+)-S-enantiomer. |
Sequence Annotation | MOTIF 380 382 Microbody targeting signal (By
ACT_SITE 152 152 Nucleophile (By similarity). |
Keyword | Complete proteome; Direct protein sequencing; Isomerase; Mitochondrion; Peroxisome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 382 AA |
Protein Sequence | MALRGVRVLE LAGLAPGPFC GMILADFGAE VVLVDRLGSV NHPSHLARGK RSLALDLKRS 60
PGAAVLRRMC ARADVLLEPF RCGVMEKLQL GPETLRQDNP KLIYARLSGF GQSGIFSKVA 120
GHDINYVALS GVLSKIGRSG ENPYPPLNLL ADFGGGGLMC TLGILLALFE RTRSGLGQVI 180
DANMVEGTAY LSTFLWKTQA MGLWAQPRGQ NLLDGGAPFY TTYKTADGEF MAVGAIEPQF 240
YTLLLKGLGL ESEELPSQMS IEDWPEMKKK FADVFARKTK AEWCQIFDGT DACVTPVLTL 300
EEALHHQHNR ERGSFITDEE QHACPRPAPQ LSRTPAVPSA KRDPSVGEHT VEVLKDYGFS 360
QEEIHQLHSD RIIESNKLKA NL 382 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:RGD. GO:0005777; C:peroxisome; IDA:HGNC. GO:0008111; F:alpha-methylacyl-CoA racemase activity; IDA:RGD. GO:0006699; P:bile acid biosynthetic process; IDA:RGD. GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |