CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031500
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Condensin complex subunit 2 
Protein Synonyms/Alias
 cDNA FLJ51440, highly similar to Condensin complex subunit 2 
Gene Name
 NCAPH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MSEILKQKDTEPTNFubiquitination[1]
16DTEPTNFKVAAGTLDubiquitination[1]
27GTLDASTKIYAVRVDubiquitination[1]
49RVLGGLGKDAPSLEEubiquitination[1]
74TEMGTTKKAVKPKKKubiquitination[1]
102NVSEADRKCEIDPMFubiquitination[1]
258HEEFRSWKEPCQVQSubiquitination[1]
288MCPLLSMKPGEYSYFubiquitination[1, 2]
352DVYFRKTKAATILTKubiquitination[1, 3]
359KAATILTKSTLENQNubiquitination[4]
396KPGTRLLKMAQGHRVubiquitination[1]
494AEPQKVNKIEIHYAKacetylation[5]
501KIEIHYAKTAKKMDMacetylation[6]
501KIEIHYAKTAKKMDMubiquitination[1, 3]
504IHYAKTAKKMDMKKLubiquitination[1]
512KMDMKKLKQSMWSLLubiquitination[1]
538ANHREAGKEAALAEVacetylation[5, 6]
538ANHREAGKEAALAEVubiquitination[1, 3]
549LAEVADEKMLSGLTKubiquitination[1]
556KMLSGLTKDLQRSLPacetylation[6]
589LANEKNLKLEGTEDLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MSEILKQKDT EPTNFKVAAG TLDASTKIYA VRVDAVHADV YRVLGGLGKD APSLEEVEGH 60
VADGSATEMG TTKKAVKPKK KHLHRTIEQN INNLNVSEAD RKCEIDPMFQ KTAASFDECS 120
TAGVFLSTLH CQDYRSELLF PSDVQTLSTG EPLELPELGC VEMTDLKAPL QQCAEDRQIC 180
PSLAGFQFTQ WDSETHNESV SALVDKFKKN DQVFDINAEV DESDCGDFPD GSLGDDFDAN 240
DEPDHTAVGD HEEFRSWKEP CQVQSCQEEM ISLGDGDIRT MCPLLSMKPG EYSYFSPRTM 300
SMWAGPDHWR FRPRRKQDAP SQSENKKKST KKDFEIDFED DIDFDVYFRK TKAATILTKS 360
TLENQNWRAT TLPTDFNYNV DTLVQLHLKP GTRLLKMAQG HRVETEHYEE IEDYDYNNPN 420
DTSNFCPGLQ AADSDDEDLD DLFVGPVGNS DLSPYPCHPP KTAQQNGDTP EAQGLDITTY 480
GESNLVAEPQ KVNKIEIHYA KTAKKMDMKK LKQSMWSLLT ALSGKEADAE ANHREAGKEA 540
ALAEVADEKM LSGLTKDLQR SLPPVMAQNL SIPLAFACLL HLANEKNLKL EGTEDLSDVL 600
VRQGD 605 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA. 
Interpro
 IPR022816; Condensin_barren_su2. 
Pfam
 PF05786; Cnd2 
SMART
  
PROSITE
  
PRINTS