UniProt Accession

 THAP1_MOUSE; Q8CHW1 

Genbank Protein ID

 BC038639 

Genbank Nucleotide ID

 AAH38639.1 

Protein Name

 THAP domain-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 Thap1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	FKRECNNKLLKENAV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). 

Sequence Annotation

 ZN_FING 5 57 THAP-type.
 MOTIF 131 134 HCFC1-binding motif (HBM) (By  

Keyword

 Cell cycle; Coiled coil; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0001935; P:endothelial cell proliferation; ISS:UniProtKB.
 GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; ISS:UniProtKB. 

Interpro

 IPR026516; THAP1.
 IPR006612; Znf_C2CH. 

Pfam

 PF05485; THAP 

SMART

 SM00692; DM3
 SM00980; THAP 

PROSITE

 PS50950; ZF_THAP 

PRINTS